Lai Fang, Ren Yang, Lai Chengzhi, Chen Rui, Yin Xuelian, Tan Caixia, Li Jiansen, Yang Chunmei, Liang Guorong, Li Jun, Zeng Ruifeng
The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou 510120, Guangdong, China.
Evid Based Complement Alternat Med. 2020 Mar 7;2020:3620741. doi: 10.1155/2020/3620741. eCollection 2020.
Sepsis is a global major health problem with high mortality rates. More effective therapy is needed for treating sepsis. Acupuncture has been used for various diseases, including severe infection, in China for more than 2,000 years. Previous studies reported that acupuncture at Zusanli (ST36) might be effective in treating sepsis, but the efficacy and the quality of evidence remain unclear since there is no systematic review on acupuncture at ST36 for sepsis.
Seven databases were searched from the inception of each database up to May 2019. Ultimately, 54 studies using acupuncture at ST36 for the treatment of experimental sepsis were identified in both English and Chinese literature with systematic review procedures.
Acupuncture might be useful in reducing injuries induced by sepsis in cardiac, lung, kidney, liver, gastrointestinal tract, and immune system. Its potential mechanisms for antisepsis might include reducing oxidative stress and inflammation, improving microcirculatory disturbance, and maintaining the immune balance mediated by dopamine. However, the positive findings should be interpreted with caution due to poor methodological quality and publication bias.
Acupuncture at ST36 might be a promising complementary strategy for controlling sepsis inflammation, yet further studies are needed.
脓毒症是一个全球性的重大健康问题，死亡率很高。治疗脓毒症需要更有效的疗法。在中国，针灸用于包括严重感染在内的各种疾病已有2000多年的历史。先前的研究报告称，针刺足三里（ST36）可能对治疗脓毒症有效，但由于尚无关于针刺ST36治疗脓毒症的系统评价，其疗效和证据质量仍不明确。
检索了7个数据库，检索时间从各数据库建库至2019年5月。最终，通过系统评价程序在英文和中文文献中确定了54项使用针刺ST36治疗实验性脓毒症的研究。
针刺可能有助于减轻脓毒症对心脏、肺、肾、肝、胃肠道和免疫系统造成的损伤。其抗感染的潜在机制可能包括减轻氧化应激和炎症、改善微循环障碍以及维持多巴胺介导的免疫平衡。然而，由于方法学质量较差和发表偏倚，对这些阳性结果应谨慎解读。
针刺ST36可能是控制脓毒症炎症的一种有前景的辅助策略，但仍需进一步研究。
