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灵芝对睾丸扭转/复位所致缺血再灌注（I/R）损伤的保护作用。

The protective effect of Ganoderma lucidum on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.

作者信息

Doğan Gül, İpek Hülya

机构信息

MD, Hitit University Faculty of Medicine , Department of Pediatric Surgery , Çorum , Turkey . Acquisition of data, manuscript writing.

MD, Hitit University Erol Olcok Training and Research Hospital , Department of Pediatric Surgery , Çorum , Turkey . Acquisition of data, manuscript preparation.

出版信息

Acta Cir Bras. 2020 Mar 20;35(1):e202000103. doi: 10.1590/s0102-865020200010000003. eCollection 2020.

DOI:10.1590/s0102-865020200010000003
PMID:32215464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7092665/
Abstract

PURPOSE

To investigate the protective effect of Ganoderma lucidum on testicular torsion/detorsion (T/D)-induced ischemia-reperfusion (I/R) injury.

METHODS

Thirty male Wistar albino rats were randomly categorized into 3 groups: Group 1: sham, Group 2 ( T/D): 2,5 hours of ischemia and 7 days of reperfusion, Group 3 (T/D+ G. lucidum ): 2,5 hours of ischemia and 7 days of reperfusion and 7 days of 20 mg/kg via gastric gavage G. lucidum polysaccharides per day. Biochemical assays of Malondialdehyde (MDA), superoxide dismutase (SOD), Catalase (CAT), Glutathione (GSH) levels , histopathology and expression levels of VEGF and Bcl-2 with immunohistochemical methods were examined in testicular tissue.

RESULTS

G. lucidum treatment was found to have prevented the T/D-induced I/R injury by decreasing MDA levels of the testis. SOD, CAT and GSH activities were decreased in group 2, while they were increased in group 3 (p<0.001) and significant improvement in the tube diameter was observed in group 3. Bcl-2-positive germinal cells were lowered in group 3 compared to the group 2. VEGF expression showed an increase in group 2, whereas it decreased in group 3.

CONCLUSION

The antioxidant G. lucidum is thought to induce angiogenesis by reducing the apoptotic effect in testicular torsion-detorsion.

摘要

目的

研究灵芝对睾丸扭转/复位（T/D）诱导的缺血再灌注（I/R）损伤的保护作用。

方法

将30只雄性Wistar白化大鼠随机分为3组：第1组：假手术组；第2组（T/D组）：缺血2.5小时，再灌注7天；第3组（T/D + 灵芝组）：缺血2.5小时，再灌注7天，且每天经胃管饲20mg/kg灵芝多糖，持续7天。检测睾丸组织中丙二醛（MDA）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽（GSH）水平的生化指标，采用免疫组化方法检测VEGF和Bcl-2的组织病理学及表达水平。

结果

发现灵芝治疗可通过降低睾丸MDA水平预防T/D诱导的I/R损伤。第2组SOD、CAT和GSH活性降低，而第3组升高（p<0.001），且第3组观察到管径有显著改善。与第2组相比，第3组Bcl-2阳性生殖细胞减少。第2组VEGF表达增加，而第3组降低。

结论

抗氧化剂灵芝被认为通过减少睾丸扭转-复位中的凋亡作用来诱导血管生成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/7092665/56cd888073c0/1678-2674-acb-35-1-e202000103-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/7092665/2d2023ec1e5f/1678-2674-acb-35-1-e202000103-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/7092665/a1a157e8b79b/1678-2674-acb-35-1-e202000103-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/7092665/56cd888073c0/1678-2674-acb-35-1-e202000103-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/7092665/2d2023ec1e5f/1678-2674-acb-35-1-e202000103-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/7092665/a1a157e8b79b/1678-2674-acb-35-1-e202000103-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/7092665/56cd888073c0/1678-2674-acb-35-1-e202000103-gf03.jpg

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