心脏发育和小儿心力衰竭中失调的 microRNAs 和长非编码 RNAs。
Dysregulated micro-RNAs and long noncoding RNAs in cardiac development and pediatric heart failure.
机构信息
Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
出版信息
Am J Physiol Heart Circ Physiol. 2020 May 1;318(5):H1308-H1315. doi: 10.1152/ajpheart.00511.2019. Epub 2020 Mar 27.
Abstract
Noncoding RNAs (ncRNAs) are broadly described as RNA molecules that are not translated into protein. The investigation of dysregulated ncRNAs in human diseases such as cancer, neurological, and cardiovascular diseases has been under way for well over a decade. Micro-RNAs and long noncoding RNAs (lncRNAs) are the best characterized ncRNAs. These ncRNAs can have profound effects on the regulation of gene expression during cardiac development and disease. Importantly, ncRNAs are significant regulators of gene expression in several congenital heart diseases and can positively or negatively impact cardiovascular development. In this review, we focus on literature involving micro-RNAs and lncRNAs in the context of pediatric cardiovascular diseases, preclinical models of heart failure, and cardiac development.
摘要
非编码 RNA（ncRNA）通常被描述为不能翻译成蛋白质的 RNA 分子。十多年来，人们一直在研究 ncRNA 在癌症、神经和心血管疾病等人类疾病中的失调情况。microRNAs 和长非编码 RNA（lncRNA）是研究得最为透彻的 ncRNA。这些 ncRNA 在心脏发育和疾病过程中对基因表达的调控有深远的影响。重要的是，ncRNA 是几种先天性心脏病中基因表达的重要调控因子，可以对心血管发育产生积极或消极的影响。在这篇综述中，我们主要关注与儿科心血管疾病、心力衰竭的临床前模型和心脏发育相关的 microRNA 和 lncRNA 的文献。
相似文献
1
Dysregulated micro-RNAs and long noncoding RNAs in cardiac development and pediatric heart failure.心脏发育和小儿心力衰竭中失调的 microRNAs 和长非编码 RNAs。
Am J Physiol Heart Circ Physiol. 2020 May 1;318(5):H1308-H1315. doi: 10.1152/ajpheart.00511.2019. Epub 2020 Mar 27.
2
Noncoding RNAs in Cardiac Hypertrophy and Heart Failure.非编码 RNA 在心肌肥厚和心力衰竭中的作用。
Cells. 2022 Feb 23;11(5):777. doi: 10.3390/cells11050777.
3
Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery.解码心脏成熟过程中的长链非编码RNA：功能发现路线图
Circ Cardiovasc Genet. 2016 Oct;9(5):395-407. doi: 10.1161/CIRCGENETICS.115.001363. Epub 2016 Sep 2.
4
Long noncoding RNA: a new player of heart failure?长非编码 RNA：心力衰竭的新角色？
J Cardiovasc Transl Res. 2013 Dec;6(6):876-83. doi: 10.1007/s12265-013-9488-6. Epub 2013 Jul 9.
5
Noncoding RNAs: potential regulators in cardioncology.非编码 RNA：心脏肿瘤学中的潜在调控因子。
Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H160-H168. doi: 10.1152/ajpheart.00418.2018. Epub 2018 Nov 9.
6
Noncoding RNA as regulators of cardiac fibrosis: current insight and the road ahead.非编码RNA作为心脏纤维化的调节因子：当前见解与未来之路
Pflugers Arch. 2016 Jun;468(6):1103-11. doi: 10.1007/s00424-016-1792-y. Epub 2016 Jan 20.
7
Interplay Between Long Noncoding RNAs and MicroRNAs in Cancer.长链非编码RNA与微小RNA在癌症中的相互作用
Methods Mol Biol. 2018;1819:75-92. doi: 10.1007/978-1-4939-8618-7_4.
8
Noncoding RNAs in Heart Failure.心力衰竭中的非编码RNA
Handb Exp Pharmacol. 2017;243:423-445. doi: 10.1007/164_2016_99.
9
Long noncoding RNAs (LncRNAs) - The dawning of a new treatment for cardiac hypertrophy and heart failure.长链非编码 RNA（LncRNAs）——心脏肥大和心力衰竭治疗的新曙光。
Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):2078-2084. doi: 10.1016/j.bbadis.2017.02.024. Epub 2017 Mar 1.
10
The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling.非编码RNA在病理性心脏重塑中的作用及分子机制
Int J Mol Sci. 2017 Mar 10;18(3):608. doi: 10.3390/ijms18030608.
引用本文的文献
1
Advances in understanding and managing pediatric heart failure and transplant.理解和管理儿科心力衰竭和移植的进展。
Curr Opin Pediatr. 2024 Oct 1;36(5):489-495. doi: 10.1097/MOP.0000000000001393. Epub 2024 Aug 12.
2
Posttranscriptional Regulation by Proteins and Noncoding RNAs.蛋白质和非编码 RNA 的转录后调控。
Adv Exp Med Biol. 2024;1441:313-339. doi: 10.1007/978-3-031-44087-8_17.
3
ASXL3 gene mutations inhibit cell proliferation and promote cell apoptosis in mouse cardiomyocytes by upregulating lncRNA NONMMUT063967.2.ASXL3基因突变通过上调lncRNA NONMMUT063967.2抑制小鼠心肌细胞的增殖并促进其凋亡。
Biochem Biophys Rep. 2023 Jun 27;35:101505. doi: 10.1016/j.bbrep.2023.101505. eCollection 2023 Sep.
4
Clinical Significance of MicroRNAs, Long Non-Coding RNAs, and CircRNAs in Cardiovascular Diseases.microRNAs、长链非编码 RNAs 和环状 RNAs 在心血管疾病中的临床意义。
Cells. 2023 Jun 14;12(12):1629. doi: 10.3390/cells12121629.
5
Air Pollution: Role of Extracellular Vesicles-Derived Non-Coding RNAs in Environmental Stress Response.空气污染：细胞外囊泡衍生的非编码 RNA 在环境应激反应中的作用。
Cells. 2023 May 29;12(11):1498. doi: 10.3390/cells12111498.
6
Circulating microRNA: Myocardium-derived prenatal biomarker of ventricular septal defects.循环微RNA：室间隔缺损的心肌源性产前生物标志物。
Front Genet. 2022 Aug 11;13:899034. doi: 10.3389/fgene.2022.899034. eCollection 2022.
7
LncRNA MEG8 sponging miR-181a-5p contributes to M1 macrophage polarization by regulating SHP2 expression in Henoch-Schonlein purpura rats.LncRNA MEG8 通过调控 SHP2 表达促进 Henoch-Schonlein 紫癜大鼠 M1 型巨噬细胞极化。
Ann Med. 2021 Dec;53(1):1576-1588. doi: 10.1080/07853890.2021.1969033.
本文引用的文献
1
Potential association of long noncoding RNA HA117 with tetralogy of Fallot.长链非编码RNA HA117与法洛四联症的潜在关联。
Genes Dis. 2018 Mar 10;5(2):185-190. doi: 10.1016/j.gendis.2018.03.002. eCollection 2018 Jun.
2
The Long Noncoding RNA CAREL Controls Cardiac Regeneration.长非编码 RNA CAREL 控制心脏再生。
J Am Coll Cardiol. 2018 Jul 31;72(5):534-550. doi: 10.1016/j.jacc.2018.04.085. Epub 2018 Jul 2.
3
Recombinant human brain natriuretic peptide regulates PI3K/AKT/mTOR pathway through lncRNA EGOT to attenuate hypoxia-induced injury in H9c2 cardiomyocytes.重组人脑利钠肽通过长链非编码 RNA EGOT 调控 PI3K/AKT/mTOR 通路减轻 H9c2 心肌细胞缺氧损伤。
Biochem Biophys Res Commun. 2018 Sep 10;503(3):1186-1193. doi: 10.1016/j.bbrc.2018.07.023. Epub 2018 Jul 18.
4
Post-transcriptional Modulation of Sphingosine-1-Phosphate Receptor 1 by miR-19a Affects Cardiovascular Development in Zebrafish.miR-19a对1-磷酸鞘氨醇受体1的转录后调控影响斑马鱼的心血管发育。
Front Cell Dev Biol. 2018 Jun 5;6:58. doi: 10.3389/fcell.2018.00058. eCollection 2018.
5
The Role of Xist in X-Chromosome Dosage Compensation.Xist 在 X 染色体剂量补偿中的作用。
Trends Cell Biol. 2018 Dec;28(12):999-1013. doi: 10.1016/j.tcb.2018.05.005. Epub 2018 Jun 14.
6
Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease.分析 miRNA 特征驱动先天性心脏病绵羊模型适应性右心室肥厚
Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H847-H854. doi: 10.1152/ajpheart.00057.2018. Epub 2018 Jun 15.
7
MicroRNA in cardiovascular biology and disease.心血管生物学与疾病中的微小RNA
Adv Clin Exp Med. 2017 Aug;26(5):865-874. doi: 10.17219/acem/62915.
8
A TBX5 3'UTR variant increases the risk of congenital heart disease in the Han Chinese population.一种TBX5 3'非翻译区变异体增加了汉族人群患先天性心脏病的风险。
Cell Discov. 2017 Jul 25;3:17026. doi: 10.1038/celldisc.2017.26. eCollection 2017.
9
Downregulation of microRNA‑199a‑5p protects cardiomyocytes in cyanotic congenital heart disease by attenuating endoplasmic reticulum stress.微小RNA-199a-5p的下调通过减轻内质网应激来保护青紫型先天性心脏病中的心肌细胞。
Mol Med Rep. 2017 Sep;16(3):2992-3000. doi: 10.3892/mmr.2017.6934. Epub 2017 Jul 6.
10
Identification of differentially expressed lncRNAs involved in transient regeneration of the neonatal C57BL/6J mouse heart by next-generation high-throughput RNA sequencing.通过下一代高通量RNA测序鉴定参与新生C57BL/6J小鼠心脏短暂再生的差异表达长链非编码RNA
Oncotarget. 2017 Apr 25;8(17):28052-28062. doi: 10.18632/oncotarget.15887.
Zotero 插件