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在初级保健中就诊的腰痛患者预后不良的预测指标。

Prognostic indicators for poor outcomes in low back pain patients consulted in primary care.

机构信息

Physiotherapy Department, Setúbal Polytechnic Institute, Setúbal, Portugal.

Comprehensive Health Research Center, CHRC, Lisbon, Portugal.

出版信息

PLoS One. 2020 Mar 27;15(3):e0229265. doi: 10.1371/journal.pone.0229265. eCollection 2020.

Abstract

BACKGROUND

Non-specific low back pain (NSLBP) is the most prevalent musculoskeletal condition in western countries and is associated with persistent disability and high consumption of health care resources. NSLBP patients first seek primary health care services but the outcomes are often uncertain. This study aimed to examine the clinical course of the outcomes and to identify prognostic indicators for poor outcomes in NSLBP patients who consulted primary care.

METHODS

A prospective cohort study of 115 patients seeking treatment for NSLBP in primary care was conducted. Participants were consecutively recruited by their General Practitioners (GPs) and then assessed at baseline and 2 and 6 months later. Baseline assessment included socio-demographic and clinical data, psychosocial factors, pain, disability, and health related quality of life (HRQoL). Pain, disability, HRQoL and global perception of change were also assessed at 2 and 6-months' follow-up. In addition, information regarding the GP' practice was collected. Poor outcomes were determined according to the cut-off point used to define a persistent disabling condition and the minimal important change established for disability, pain and for global perception of change. The relationship between variables on baseline and poor outcomes was modulated through binary logistic regression analysis. The significance of associations was evaluated at ≤ 0.05 p-value with 95% confidence intervals (CI) and adjusted odds ratios (AOR).

RESULTS

110 (94.8%) and 104 (89.7%) participants completed the follow-up assessment at 2 and 6 months, respectively. The mean age (±SD) was 48.06 ± 11.41, with 53.9%, (N = 62) reporting an acute presentation of NSLBP. Six months after GP consultation, 53.8% (N = 56) of the participants reported a persistent disabling condition. An "LBP episode of less than 12 weeks" [AOR: 0.26; 95% CI (0.10, 0.65); AOR: 0.34; 95% CI (0.14, 0.81); AOR: 0.21; 95% CI (0.09, 0.53)],"maladaptive psychosocial factors" [AOR: 2.06; 95% CI (1.40, 3.04); AOR: 1.82; 95% CI (1.27, 2.59); AOR: 1.72; 95% CI (1.20, 2.47)] were significantly associated with poor outcomes on disability, pain and global perception of change, respectively. Besides these factors, being employed reduces the chances of poor outcomes on disability [AOR 0.31; 95% CI (0.11, 0.92)].

CONCLUSIONS

A large proportion of LBP patients seeking primary health care reported poor outcomes 6 months after GP consultation. Patients who report chronic LBP, maladaptive psychosocial factors and are unemployed have a significant increase in the risk of poor outcome. These findings suggest the need of implementing effective models of care able to provide early screening and appropriate treatment to those at greatest risk of a poor outcome.

TRIAL REGISTRATION

Current Controlled Trials NCT04046874 (August 6, 2019). Retrospectively registered.

摘要

背景

非特异性下腰痛(NSLBP)是西方国家最常见的肌肉骨骼疾病,与持续残疾和高医疗保健资源消耗有关。NSLBP 患者首先寻求初级卫生保健服务,但结果往往不确定。本研究旨在检查结局的临床过程,并确定在初级保健中就诊的 NSLBP 患者不良结局的预后指标。

方法

对在初级保健中因 NSLBP 就诊的 115 例患者进行前瞻性队列研究。参与者由他们的全科医生(GP)连续招募,然后在基线、2 个月和 6 个月后进行评估。基线评估包括社会人口学和临床数据、心理社会因素、疼痛、残疾和健康相关生活质量(HRQoL)。在 2 个月和 6 个月的随访中还评估了疼痛、残疾、HRQoL 和整体变化感知。此外,还收集了有关 GP 实践的信息。根据用于定义持续性致残状况的截止值和为残疾、疼痛和整体变化感知确定的最小重要变化来确定不良结局。通过二元逻辑回归分析调节基线和不良结局之间的变量关系。关联的显著性评估为≤0.05 的 p 值,置信区间(CI)和调整后的优势比(AOR)为 95%。

结果

110(94.8%)和 104(89.7%)名参与者分别在 2 个月和 6 个月时完成了随访评估。平均年龄(±SD)为 48.06±11.41,53.9%(N=62)报告 NSLBP 的急性发作。在 GP 咨询后 6 个月,53.8%(N=56)的参与者报告存在持续性致残状况。“LBP 发作时间少于 12 周”[AOR:0.26;95%CI(0.10,0.65);AOR:0.34;95%CI(0.14,0.81);AOR:0.21;95%CI(0.09,0.53)],“适应不良的心理社会因素”[AOR:2.06;95%CI(1.40,3.04);AOR:1.82;95%CI(1.27,2.59);AOR:1.72;95%CI(1.20,2.47)]与残疾、疼痛和整体变化感知的不良结局显著相关。除这些因素外,就业减少了残疾不良结局的可能性[OR 0.31;95%CI(0.11,0.92)]。

结论

大量寻求初级卫生保健的 LBP 患者在 GP 咨询后 6 个月报告不良结局。报告慢性 LBP、适应不良的心理社会因素和失业的患者不良结局风险显著增加。这些发现表明需要实施有效的护理模式,以便为那些最有可能出现不良结局的患者提供早期筛查和适当的治疗。

试验注册

当前对照试验 NCT04046874(2019 年 8 月 6 日)。回顾性注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd01/7100970/b9e1f889e51c/pone.0229265.g001.jpg

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