Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Amecameca de Juárez, Estado de México, México.
Centro Veterinario México, Benito Juárez, Cd. de los Deportes, Ciudad de México, México.
PLoS One. 2020 Mar 27;15(3):e0230753. doi: 10.1371/journal.pone.0230753. eCollection 2020.
Rabbits (Oryctolagus cuniculi) are very popular as pets. However, problems of otitits caused by Psoroptes cuniculi are one of the main reasons to visit the veterinarian. Isoxazolines are an alternative treatment to treat this mite, and therefore, an evaluation of the effectiveness of oral afoxalaner with milbemycin oxime in rabbits infected with P. cuniculi was carried out. Nineteen rabbits, of New Zealand breed, with otitis due to an infection with P. cuniculi, were treated, whereas six rabbits were left untreated and formed the control group. The ear canals of each individual were examined, through the collection of otic exudate samples with cotton swabs. These were visualized under the microscope to identify the ectoparasite. Each animal was treated with a single oral dose of 2.50 mg / kg of afoxolaner, and 0.50 mg / kg of milbemycin oxime. Clinical signs and lesions associated with the infection, such as the presence of detritus, cerumen and / or scabs, and erythema, were evaluated. After receiving the treatment, all the lesions were classified as: mild, moderate and intense, with a visual analog scale. A week after providing medication, there was a decrease in the lesions of the group treated with Nexgard Spectra®, without further topical or systemic treatment. The decrease was gradual in the treated group and no recurrence was detected of P. cuniculi infection in both ears. Thus, the administration of a single oral dose of afoxolaner with milbemycin oxime was effective for the treatment of P. cuniculi infection in rabbits.
兔子（Oryctolagus cuniculi）是非常受欢迎的宠物。然而，由Psoroptes cuniculi引起的耳炎是导致兔子去看兽医的主要原因之一。异恶唑啉类药物是治疗这种螨虫的一种替代疗法，因此，评估了口服阿福拉纳和米尔贝肟治疗感染 P. cuniculi 的兔子的有效性。对 19 只患有 P. cuniculi 感染引起的耳炎的新西兰兔进行了治疗，而 6 只兔子未接受治疗，作为对照组。用棉签从每个个体的耳道中收集耳垢样本，通过显微镜观察这些样本，以识别外寄生虫。每只动物口服 2.50 毫克/千克的阿福拉纳和 0.50 毫克/千克的米尔贝肟进行单次治疗。评估与感染相关的临床症状和病变，如碎屑、耳垢和/或痂皮以及红斑的存在。接受治疗后，所有病变均根据病变严重程度分为轻度、中度和重度，并采用视觉模拟量表进行评估。在给药后一周，用 Nexgard Spectra®治疗的组的病变减少，无需进一步的局部或全身治疗。在治疗组中，病变逐渐减轻，并且在两只耳朵中都没有发现 P. cuniculi 感染的复发。因此，单次口服阿福拉纳和米尔贝肟的给药对治疗感染 P. cuniculi 的兔子有效。
