Naqvi Syeda Uzma, Khan Saeed, Ahmed Ayaz, Lail Amanullah, Gul Saima, Ahmed Sagheer
Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Department of Physical Therapy, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
J Med Virol. 2020 Dec;92(12):3880-3883. doi: 10.1002/jmv.25791. Epub 2020 Apr 10.
Many studies have proposed an important role of viruses in the pathogenesis of oral cancer. The present study aimed to find out the prevalence of Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human papillomavirus (HPV) among patients with oral squamous cell carcinoma (OSCC) in a Pakistani cohort. We investigated tissue samples obtained from 58 patients with OSCC using the polymerase chain reaction assay. No sample was positive for HPV. EBV was identified in 15 patients (25.86%), and CMV in three patients (5.17%). Coinfection with one or more viruses was detected in two cases and was coinfection with EBV and CMV. These results suggest a low prevalence of these viruses in OSCC patients in the Pakistani population compared to most other countries where the prevalence of these viruses has been reported in the past. Nevertheless, further studies are necessary to determine the potential role of EBV and the possible importance of CMV as an infection cofactor in oral cancer.
许多研究都提出病毒在口腔癌发病机制中起重要作用。本研究旨在查明巴基斯坦人群队列中口腔鳞状细胞癌（OSCC）患者中爱泼斯坦-巴尔病毒（EBV）、巨细胞病毒（CMV）和人乳头瘤病毒（HPV）的感染率。我们使用聚合酶链反应检测法对58例OSCC患者的组织样本进行了调查。没有样本HPV呈阳性。15例患者（25.86%）检测出EBV，3例患者（5.17%）检测出CMV。在2例病例中检测到一种或多种病毒合并感染，均为EBV和CMV合并感染。这些结果表明，与过去报告过这些病毒感染率的大多数其他国家相比，巴基斯坦人群中OSCC患者的这些病毒感染率较低。尽管如此，仍需进一步研究以确定EBV的潜在作用以及CMV作为口腔癌感染辅助因子的可能重要性。
