Wnuk Anna, Stangret Aleksandra, Wątroba Mateusz, Płatek Anna E, Skoda Marta, Cendrowski Krzysztof, Sawicki Włodzimierz, Szukiewicz Dariusz
Chair and Department of Obstetrics, Gynecology and Oncology, Medical University of Warsaw, Warsaw, Poland.
Chair and Department of General and Experimental Pathology with Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland.
Obes Rev. 2020 Jul;21(7):e13022. doi: 10.1111/obr.13022. Epub 2020 Mar 27.
Overweight and obesity have become a dangerous disease requiring multiple interventions, treatment and preventions. In women of reproductive age, obesity is one of the most common medical conditions. Among others, obese state is characterized by low-grade systemic inflammation and enhanced oxidative stress. Increased maternal body mass index might amplify inflammation and reactive oxygen species production, which is associated with unfavourable clinical outcomes that affect both mother and child. Intrauterine growth retardation, preeclampsia, or gestational diabetes mellitus are examples of the hampered maternal and foetoplacental unit interactions. Visfatin is the obesity-related adipokine produced mainly by the visceral adipose tissue. Visfatin affects glucose homeostasis, as well as the regulation of genes related to oxidative stress and inflammatory response. Here, we review visfatin interactions in pregnancy-related disorders linked to obesity. We highlight the possible predictive and prognostic value of visfatin in diagnostic strategies on gravidas with obesity.
超重和肥胖已成为一种需要多种干预、治疗和预防措施的危险疾病。在育龄女性中，肥胖是最常见的病症之一。其中，肥胖状态的特征是低度全身炎症和氧化应激增强。孕妇体重指数增加可能会加剧炎症和活性氧的产生，这与影响母婴的不良临床结局有关。宫内生长受限、先兆子痫或妊娠期糖尿病是母婴和胎盘-胎儿单位相互作用受阻的例子。内脂素是主要由内脏脂肪组织产生的与肥胖相关的脂肪因子。内脂素影响葡萄糖稳态以及与氧化应激和炎症反应相关基因的调控。在此，我们综述内脂素在与肥胖相关的妊娠疾病中的相互作用。我们强调内脂素在肥胖孕妇诊断策略中的可能预测和预后价值。
