Chen Qin, Du Yongjing, Prince Singh, Zhang Ping, Li Guisen, Wang Li, Wang Wei
Department of Nephrology and Institute of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, China.
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Medicine (Baltimore). 2020 Mar;99(13):e19462. doi: 10.1097/MD.0000000000019462.
Primary mucosa-associated lymphoid tissue (MALT) lymphomas originating in thymus is rare. And, there have been few reports of patients with MALT coexisting with amyloidosis. As far as we know, this was the first case report on MALT lymphoma associated with renal amyloidosis.
A 57-year-old man presented with nephrotic syndrome. Further workup revealed IgM-Lambda type monoclonal gammopathy. Bone marrow biopsy showed 8% clonal plasma cells. Renal biopsy confirmed the diagnosis of Lambda light chain AL amyloidosis. positron emission tomography/computed tomography showed thymic lesions which upon biopsy were diagnosed as MALT lymphoma of the thymus.
Primary thymic MALT lymphoma complicated with renal amyloidosis.
The patient underwent surgical resection of the thymus mass and 2 courses of chemotherapy.
Follow-up data showed that the patient survived 18 months after surgical excision and chemotherapy.
The case highlights the importance of screening for malignancy in patients with renal amyloidosis.
起源于胸腺的原发性黏膜相关淋巴组织（MALT）淋巴瘤较为罕见。而且，关于MALT与淀粉样变性共存的患者报道较少。据我们所知，这是首例关于MALT淋巴瘤合并肾淀粉样变性的病例报告。
一名57岁男性出现肾病综合征。进一步检查发现IgM-λ型单克隆丙种球蛋白病。骨髓活检显示8%的克隆性浆细胞。肾活检确诊为λ轻链AL淀粉样变性。正电子发射断层扫描/计算机断层扫描显示胸腺病变，活检诊断为胸腺MALT淋巴瘤。
原发性胸腺MALT淋巴瘤合并肾淀粉样变性。
患者接受了胸腺肿块手术切除及2个疗程化疗。
随访数据显示，患者在手术切除及化疗后存活了18个月。
该病例突出了对肾淀粉样变性患者进行恶性肿瘤筛查的重要性。
