Tan Ruijing, Yang Xingxin, Tang Xian, Ma Wenjie, He Lifen
Kunming Medical University, Kunming, Yunnan Province, China.
Yunnan University of TCM, Kunming, Yunnan Province, China.
Medicine (Baltimore). 2020 Mar;99(13):e19582. doi: 10.1097/MD.0000000000019582.
Ramsay Hunt syndrome (RHS), also known as Hunt syndrome, is caused by varicella-zoster virus infection. The virus often invades the facial nerve geniculate ganglion to cause peripheral facial paralysis, accompanied by severe ear pain, auricular herpes zoster, tinnitus, deafness, vertigo, and other inner ear neurologic symptoms. The acupuncture has a long history as a traditional treatment of traditional Chinese medicine for the treatment of Hunt syndrome, with few adverse events and low cost. However, there are few evidences for the efficacy and safety of acupuncture for Hunt syndrome. Hence, we plan this systematic review and meta-analysis protocol to evaluate the efficacy and safety of acupuncture for Hunt syndrome.
Four English databases will be searched from their inception to February 2019, including Cochrane Library, PubMed, Embase, OVID, and 4 Chinese databases, including Chinese Biomedical Literature Database [CBM], China National Knowledge Infrastructure [CNKI], CQVIP, and Wanfang. No restriction was imposed for language or publication period. Randomized controlled clinical trials (RCTs) compared any form of acupuncture with/without additional treatment against sham or no treatment or same additional treatment. Data will be extracted and evaluated by 2 reviewers independently. RevMan 5.3 software will be used for data analysis when a meta-analysis is allowed.
This systematic review and meta-analysis will provide an evidence of acupuncture for RHS.
This study will determine whether acupuncture is an effective and safe intervention for RHS. PROSPERO registration number: CRD 42019118283.
拉姆齐·亨特综合征（RHS），也称为亨特综合征，由水痘-带状疱疹病毒感染引起。该病毒常侵犯面神经膝状神经节，导致周围性面瘫，伴有严重耳痛、耳部带状疱疹、耳鸣、耳聋、眩晕等内耳神经症状。针灸作为中医治疗亨特综合征的传统疗法历史悠久，不良事件少且成本低。然而，关于针灸治疗亨特综合征的疗效和安全性的证据较少。因此，我们制定本系统评价和荟萃分析方案，以评估针灸治疗亨特综合征的疗效和安全性。
检索4个英文数据库，从建库至2019年2月，包括考克兰图书馆、PubMed、Embase、OVID，以及4个中文数据库，包括中国生物医学文献数据库[CBM]、中国知网[CNKI]、维普资讯[CQVIP]和万方数据库。对语言或发表时间无限制。随机对照临床试验（RCTs）将任何形式的针灸与假针灸或不治疗或相同的附加治疗进行比较，有无附加治疗均可。数据将由2名 reviewers 独立提取和评估。当允许进行荟萃分析时，将使用RevMan 5.3软件进行数据分析。
本系统评价和荟萃分析将为针灸治疗RHS提供证据。
本研究将确定针灸是否是治疗RHS的有效且安全的干预措施。PROSPERO注册号：CRD 42019118283。
