Molecular Genetics Sub Department, Institute of Public Health of Chile, Santiago, Chile.
Section of Respiratory and Exanthematic Viruses, Institute of Public Health of Chile, Santiago, Chile.
J Med Virol. 2020 Sep;92(9):1562-1566. doi: 10.1002/jmv.25797. Epub 2020 Apr 8.
The current pandemic caused by the new coronavirus is a worldwide public health concern. To aboard this emergency, and like never before, scientific groups around the world have been working in a fast and coordinated way to get the maximum of information about this virus when it has been almost 3 months since the first cases were detected in Wuhan province in China. The complete genome sequences of around 450 isolates are available, and studies about similarities and differences among them and with the close related viruses that caused similar epidemics in this century. In this work, we studied the complete genome of the first four cases of the new coronavirus disease in Chile, from patients who traveled to Europe and Southeast Asia. Our findings reveal at least two different viral variants entries to Chilean territory, coming from Europe and Asia. We also sub-classified the isolates into variants according to punctual mutations in the genome. Our work contributes to global information about transmission dynamics and the importance to take control measures to stop the spread of the infection.
当前由新型冠状病毒引起的大流行是全球关注的公共卫生问题。为了应对这一紧急情况，全球各地的科学团体以前所未有的速度和协调方式开展工作，以在首次在中国湖北省发现病例近 3 个月后，尽可能多地获取有关该病毒的信息。目前已有约 450 个分离株的完整基因组序列，研究人员对这些序列与在本世纪引起类似流行病的密切相关病毒之间的相似性和差异性进行了研究。在这项工作中，我们研究了智利前四例新型冠状病毒疾病患者的完整基因组，这些患者曾前往欧洲和东南亚旅行。我们的研究结果表明，至少有两种不同的病毒变体进入智利，分别来自欧洲和亚洲。我们还根据基因组中的定点突变将分离株进一步分为变体。我们的工作有助于了解病毒传播动态的全球信息，以及采取控制措施以阻止感染传播的重要性。
