Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fujian 350007, China.
College of Life Science, Fujian Normal University, Fujian 350007, China.
Mater Sci Eng C Mater Biol Appl. 2020 Apr;109:110649. doi: 10.1016/j.msec.2020.110649. Epub 2020 Jan 7.
Adhesive hydrogels for wet and dynamic tissues are important for biomedical applications in order to withstand cyclic loading such as in the case of hemorrhaging control on the curved skins and heart tissues. However, the fabrication of hydrogels with strong mechanical properties, high adhesion strength, and hemostatic efficiency remains a big challenge. Inspired by the great adhesive behavior of mussels and Arion subfuscus, novel adhesive and hemostatic polyacrylamide-tannic acid-kaolin (PAAm-TA-KA) hydrogels were reported in this work. The hydrogels displayed high strength and toughness due to their physical and chemical crosslinking structures. The abundant catechol groups on tannic acid endow the hydrogels with strong and durable adhesion strength of up to 500 kPa on porcine skin. When applied onto human skin, the hydrogels could be easily peeled off without leaving any remains and causing any damages. The kaolin nanoparticles incorporated in the PAAm-TA-KA hydrogels not only served as a physical crosslinking agent, but an activator of the blood clotting factor FXII for accelerating the formation of thrombus. The strong tissue adhesion and blood coagulant potential of the PAAm-TA-KA hydrogels imparted them high hemostatic efficiency. The free-standing, adhesive, tough, cytocompatible, and hemostatic hydrogels are highly promising for traumatic bleeding control materials.
用于湿态和动态组织的黏附水凝胶在生物医学应用中非常重要，因为它们需要承受循环负载，例如在控制曲面上皮肤和心脏组织出血的情况下。然而，制造具有强机械性能、高黏附强度和止血效率的水凝胶仍然是一个巨大的挑战。受贻贝类和黑腹滨鹬强大黏附行为的启发，本工作报道了新型黏附止血聚丙烯酰胺-单宁酸-高岭土（PAAm-TA-KA）水凝胶。由于其物理和化学交联结构，水凝胶具有高强度和韧性。单宁酸上丰富的儿茶酚基团赋予水凝胶在猪皮上高达 500kPa 的强而持久的黏附强度。当应用于人体皮肤时，水凝胶可以轻松剥离，不会留下任何残留物，也不会造成任何损伤。高岭土纳米粒子不仅在 PAAm-TA-KA 水凝胶中充当物理交联剂，还充当凝血因子 FXII 的激活剂，加速血栓形成。PAAm-TA-KA 水凝胶的强组织黏附性和血液凝固潜力赋予其高止血效率。这种独立式、黏附性、坚韧、细胞相容性和止血水凝胶非常有希望成为创伤性出血控制材料。
