Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
Mater Sci Eng C Mater Biol Appl. 2020 Apr;109:110497. doi: 10.1016/j.msec.2019.110497. Epub 2019 Nov 27.
Lack of bioactivity and monomer toxicity are limiting factors of polymethyl methacrylate (PMMA) bone cement in orthopedic applications. Herein, we address these shortcomings by proposing two-dimensional magnesium phosphate (MgP) nanosheets and hydroxyapatite (HA) nanofibers as novel fillers in PMMA bone cement nanocomposites. Two-dimensional MgP nanosheets and one-dimensional HA nanofibers were synthesized by tuning the crystallization of the sodium-magnesium-phosphate ternary system and hydrothermal homogeneous precipitation, respectively. We show that MgP nanosheets exhibit antibacterial properties against Escherichia coli (E. coli). In addition, HA nanofibers with high level of bioactivity are the proper choice to induce cell viability in the nanocomposite. Results indicate that the combination of both fillers can act as deformation locks enhancing the compressive strength of the nanocomposites. The synthesized nanocomposite possesses excellent bioactivity, mechanical properties, and cytocompatibility potentially opening new paradigm in the design of next generation bone cement composites.
聚甲基丙烯酸甲酯（PMMA）骨水泥在骨科应用中存在生物活性不足和单体毒性的问题。在此，我们通过在 PMMA 骨水泥纳米复合材料中引入二维磷酸镁（MgP）纳米片和一维羟基磷灰石（HA）纳米纤维来解决这些缺点。二维 MgP 纳米片和一维 HA 纳米纤维是通过调整钠-镁-磷三元体系的结晶和水热均匀沉淀分别合成的。我们证明了 MgP 纳米片对大肠杆菌（E. coli）具有抗菌性能。此外，具有高生物活性的 HA 纳米纤维是诱导纳米复合材料中细胞活力的理想选择。结果表明，两种填料的结合可以作为变形锁，提高纳米复合材料的抗压强度。所合成的纳米复合材料具有优异的生物活性、机械性能和细胞相容性，为下一代骨水泥复合材料的设计开辟了新的范例。
