Duar Rebbeca M, Kyle David, Casaburi Giorgio
Evolve BioSystems, Inc., Davis, CA 95618, USA.
High Throughput. 2020 Mar 27;9(2):7. doi: 10.3390/ht9020007.
Over the past century, there has been a steady increase in the stool pH of infants from industrialized countries. Analysis of historical data revealed a strong association between abundance of in the gut microbiome of breasted infants and stool pH, suggesting that this taxon plays a key role in determining the pH in the gut. subsp. is uniquely equipped to metabolize human milk oligosaccharides (HMO) from breastmilk into acidic end products, mainly lactate and acetate. The presence of these acidic compounds in the infant gut is linked to a lower stool pH. Conversely, infants lacking have a significantly higher stool pH, carry a higher abundance of potential pathogens and mucus-eroding bacteria in their gut microbiomes, and have signs of chronic enteric inflammation. This suggests the presence of and low intestinal pH may be critical to maintaining a protective environment in the infant gut. Here, we summarize recent studies demonstrating that feeding EVC001 to breastfed infants results in significantly lower fecal pH compared to controls and propose that low pH is one critical factor in preventing the invasion and overgrowth of harmful bacteria in the infant gut, a process known as colonization resistance.
在过去的一个世纪里，工业化国家婴儿的粪便pH值一直在稳步上升。对历史数据的分析显示，母乳喂养婴儿的肠道微生物群中某一分类群的丰度与粪便pH值之间存在密切关联，这表明该分类群在决定肠道pH值方面起着关键作用。某亚种特别具备将母乳中的人乳寡糖（HMO）代谢为酸性终产物的能力，主要是乳酸和乙酸。婴儿肠道中这些酸性化合物的存在与较低的粪便pH值有关。相反，缺乏该分类群的婴儿粪便pH值明显更高，其肠道微生物群中潜在病原体和黏液侵蚀细菌的丰度更高，并且有慢性肠道炎症的迹象。这表明该分类群的存在和较低的肠道pH值可能对维持婴儿肠道的保护环境至关重要。在此，我们总结了最近的研究，这些研究表明，与对照组相比，给母乳喂养的婴儿喂食EVC001会导致粪便pH值显著降低，并提出低pH值是防止有害细菌在婴儿肠道中入侵和过度生长（这一过程称为定植抗性）的一个关键因素。
