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注射透明质酸酶成功治疗头皮黏液水肿：一例报告

Successful Treatment of Scalp Myxedema with Injected Hyaluronidase: A Case Report.

作者信息

Menzinger Sébastien, Kaya Gürkan

机构信息

Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland.

Department of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland.

出版信息

Dermatopathology (Basel). 2020 Feb 7;6(4):260-265. doi: 10.1159/000505354. eCollection 2019 Oct-Dec.

DOI:10.1159/000505354
PMID:32232032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7098337/
Abstract

Localized myxedema is an uncommon complication of Graves' disease. It is characterized by the accumulation of glycosaminoglycans, particularly hyaluronate. Here we describe the case of a 51-year-old female patient suffering from Graves' disease, who has presented for years a thickening of the scalp, consistent with myxedema, and successfully treated with repeated injections of hyaluronidase.

摘要

局限性黏液性水肿是格雷夫斯病的一种罕见并发症。其特征是糖胺聚糖尤其是透明质酸盐的积聚。在此，我们描述一例51岁患格雷夫斯病的女性患者，她多年来头皮增厚，符合黏液性水肿表现，并通过反复注射透明质酸酶成功治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc1a/7098337/c0169ca4cb6a/dpa-0006-0260-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc1a/7098337/983c474e1ef6/dpa-0006-0260-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc1a/7098337/7dd9c8e48830/dpa-0006-0260-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc1a/7098337/35bce9a956a4/dpa-0006-0260-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc1a/7098337/c0169ca4cb6a/dpa-0006-0260-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc1a/7098337/983c474e1ef6/dpa-0006-0260-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc1a/7098337/7dd9c8e48830/dpa-0006-0260-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc1a/7098337/35bce9a956a4/dpa-0006-0260-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc1a/7098337/c0169ca4cb6a/dpa-0006-0260-g04.jpg

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Successful Treatment of Scalp Myxedema with Injected Hyaluronidase: A Case Report.注射透明质酸酶成功治疗头皮黏液水肿：一例报告
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本文引用的文献

1
Pretibial myxedema successfully treated with intralesional hyaluronidase.病灶内注射透明质酸酶成功治疗胫前黏液性水肿。
JAAD Case Rep. 2018 Oct 3;4(9):874-876. doi: 10.1016/j.jdcr.2018.08.018. eCollection 2018 Oct.
2
Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema.注射透明质酸酶可减少小鼠体内外源性透明质酸填充剂的体积，并使一名胫前黏液性水肿患者的临床症状得到改善。
Dermatopathology (Basel). 2016 Jul 6;3(3):61-7. doi: 10.1159/000446699. eCollection 2016 Jul-Sep.
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Congenital Primary Essential Cutis Verticis Gyrata.
先天性原发性真性头皮回旋症
Eplasty. 2016 Apr 12;16:ic13. eCollection 2016.
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[Primary essential cutis verticis gyrata: Case report and literature review].[原发性真性头皮回旋状鱼鳞病：病例报告及文献综述]
Ann Chir Plast Esthet. 2010 Jun;55(3):243-8. doi: 10.1016/j.anplas.2009.06.010. Epub 2009 Nov 25.
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Local injections of a preparation of hyaluronidase in the treatment of localized (pretibial) myxedema.局部注射透明质酸酶制剂治疗局限性（胫前）黏液性水肿。
J Invest Dermatol. 1949 Jun;12(6):345-8. doi: 10.1038/jid.1949.53.
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Hyaluronidase offers an efficacious treatment for inaesthetic hyaluronic acid overcorrection.透明质酸酶为不美观的透明质酸过度填充提供了一种有效的治疗方法。
J Cosmet Dermatol. 2007 Sep;6(3):159-62. doi: 10.1111/j.1473-2165.2007.00332.x.
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Lipedematous scalp and lipedematous alopecia: report of three cases in white adults.脂性头皮和脂性脱发：3例白人成年人病例报告
J Dermatol. 2007 Feb;34(2):124-30. doi: 10.1111/j.1346-8138.2006.00231.x.
8
Management of injected hyaluronic acid induced Tyndall effects.注射透明质酸所致丁达尔效应的处理
Lasers Surg Med. 2006 Mar;38(3):202-4. doi: 10.1002/lsm.20283.
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Pretibial myxedema: pathophysiology and treatment options.胫前黏液性水肿：病理生理学与治疗选择
Am J Clin Dermatol. 2005;6(5):295-309. doi: 10.2165/00128071-200506050-00003.
10
Lipedematous scalp and lipedematous alopecia: a clinical and histologic analysis of 3 cases.脂性头皮和脂性脱发：3例临床及组织学分析
J Am Acad Dermatol. 2005 Jan;52(1):152-6. doi: 10.1016/j.jaad.2004.05.016.