脓毒症和感染性休克重症监护病房患者的硫醇/二硫键稳态。
Thiol/disulphide homeostasis in intensive care unit patients with sepsis and septic shock.
机构信息
Department of Internal Medical Sciences and Critical Care, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
出版信息
Turk J Med Sci. 2020 Jun 23;50(4):811-816. doi: 10.3906/sag-1905-148.
BACKGROUND/AIM: Sepsis is a condition caused by infection followed by unregulated inflammatory response which may lead to organ dysfunction. The aim of this study is to be the first in the literature and it has been designed to show the thiol/disulphide changes in patients with sepsis and septic shock and their correlation with acute phase reactants.
MATERIAL AND METHODS
A total of 113 patients (septic shock 53 and sepsis 60) and 60 healthy control subjects have been enrolled in this study from the period February 2018 to 2019. The patients were divided in 2 groups: nonsurvivors (74) and survivors (39). The investigation includes measurements of native thiol, total thiol, dynamic disulphide bond, oxidized thiol ratio, reduced thiol ratio and thiol oxidation reduction ratio, erythrocyte sedimentation rate, C-reactive protein, and procalcitonin.
RESULTS
The findings of this study suggest that changes in thiol levels play a role in the pathogenesis of patients with sepsis and septic shock.
CONCLUSIONS
Thiol/disulphide homeostasis is impaired in patients with sepsis and septic shock. Understanding the role of thiol/ disulphide homeostasis in sepsis and septic shock may provide different therapeutic intervention strategies for patients.
背景/目的：脓毒症是一种由感染引起的疾病，随后发生不受调节的炎症反应，可能导致器官功能障碍。本研究旨在首次在文献中展示脓毒症和感染性休克患者的硫醇/二硫键变化及其与急性相反应物的相关性。
材料和方法
本研究共纳入 2018 年 2 月至 2019 年期间的 113 名患者（感染性休克 53 例，脓毒症 60 例）和 60 名健康对照者。患者分为两组：非幸存者（74 例）和幸存者（39 例）。调查包括测量天然硫醇、总硫醇、动态二硫键、氧化硫醇比、还原硫醇比和硫醇氧化还原比、红细胞沉降率、C 反应蛋白和降钙素原。
结果
本研究的结果表明，硫醇水平的变化在脓毒症和感染性休克患者的发病机制中起作用。
结论
脓毒症和感染性休克患者的硫醇/二硫键平衡受损。了解硫醇/二硫键平衡在脓毒症和感染性休克中的作用可能为患者提供不同的治疗干预策略。
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