Tuzcu Ayca, Baykara Rabia Aydogan, Omma Ahmet, Acet Gunseli Karaca, Dogan Erdal, Cure Medine Cumhur, Sandikci Sevinc Can, Cure Erkan, Neşelioğlu Salim, Erel Ozcan
Department of Biochemistry, Malatya Education and Research Hospital, Malatya, Turkey.
Department of Physical Medicine and Rehabilitation, Malatya Education and Research Hospital, Malatya, Turkey.
Rom J Intern Med. 2019 Mar 1;57(1):30-36. doi: 10.2478/rjim-2018-0025.
Oxidative stress may play an important role in rheumatoid arthritis (RA) etiopathogenesis. The thiol group is a very strong antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with RA by evaluating thiol/disulfide homeostasis.
A total of 50 female RA patients and 50 healthy female controls were included in this study. Thiol and disulfide values were calculated utilizing novel methods.
Native thiol (p < 0.001) and total thiol (p < 0.001) levels of RA patients were significantly lower compared to values in the control group. However, the disulfide (p < 0.001) levels of RA patients were strongly higher than in healthy individuals. A negative correlation was found between thiol and disease activity score-28 among the patients, whereas a positive correlation was found between disulfide and disease activity score-28 among the patients.
We found that the thiol-disulfide rate deteriorated in RA patients, with the proportion of disulfide increasing. There is a strong correlation between the decrease in thiol levels, increase in disulfide levels and the disease activity scores.
氧化应激可能在类风湿关节炎（RA）的发病机制中起重要作用。硫醇基团是一种非常强的抗氧化剂。在本研究中，我们旨在通过评估硫醇/二硫键稳态来研究RA患者体内氧化应激的存在情况。
本研究共纳入50例女性RA患者和50例健康女性对照。采用新方法计算硫醇和二硫键值。
与对照组相比，RA患者的天然硫醇（p < 0.001）和总硫醇（p < 0.001）水平显著降低。然而，RA患者的二硫键（p < 0.001）水平明显高于健康个体。患者中硫醇与疾病活动评分-28呈负相关，而二硫键与疾病活动评分-28呈正相关。
我们发现RA患者的硫醇-二硫键比率恶化，二硫键比例增加。硫醇水平降低、二硫键水平升高与疾病活动评分之间存在密切相关性。
