类风湿关节炎患者的硫醇/二硫键稳态

Thiol/Disulfide homeostasis in patients with rheumatoid arthritis.

作者信息

Tuzcu Ayca, Baykara Rabia Aydogan, Omma Ahmet, Acet Gunseli Karaca, Dogan Erdal, Cure Medine Cumhur, Sandikci Sevinc Can, Cure Erkan, Neşelioğlu Salim, Erel Ozcan

机构信息

Department of Biochemistry, Malatya Education and Research Hospital, Malatya, Turkey.

Department of Physical Medicine and Rehabilitation, Malatya Education and Research Hospital, Malatya, Turkey.

出版信息

Rom J Intern Med. 2019 Mar 1;57(1):30-36. doi: 10.2478/rjim-2018-0025.

DOI:10.2478/rjim-2018-0025

PMID:30375356

Abstract

BACKGROUND

Oxidative stress may play an important role in rheumatoid arthritis (RA) etiopathogenesis. The thiol group is a very strong antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with RA by evaluating thiol/disulfide homeostasis.

MATERIAL AND METHODS

A total of 50 female RA patients and 50 healthy female controls were included in this study. Thiol and disulfide values were calculated utilizing novel methods.

RESULTS

Native thiol (p < 0.001) and total thiol (p < 0.001) levels of RA patients were significantly lower compared to values in the control group. However, the disulfide (p < 0.001) levels of RA patients were strongly higher than in healthy individuals. A negative correlation was found between thiol and disease activity score-28 among the patients, whereas a positive correlation was found between disulfide and disease activity score-28 among the patients.

CONCLUSION

We found that the thiol-disulfide rate deteriorated in RA patients, with the proportion of disulfide increasing. There is a strong correlation between the decrease in thiol levels, increase in disulfide levels and the disease activity scores.

摘要