Danielczyk W, Streifler M, Konradi C, Riederer P, Moll G
Department of Neurology, Lainz Geriatric Hospital, Vienna, Austria.
Acta Psychiatr Scand. 1988 Dec;78(6):730-6. doi: 10.1111/j.1600-0447.1988.tb06412.x.
Monoamine oxidase-B (MAO-B) activity of platelets of an age- and sex-matched group of controls was compared with several groups of inpatients having non-familial dementia of Alzheimer type (DAT), Parkinson's disease (PD), multi-infarct dementia (MID), mixed types of these 3 diseases and a group of other central nervous system (CNS) organic disorders. All patients were subjected to several psychometric tests, including the Sandoz Clinical Assessment--Geriatric Scale, Hamilton Rating Scale for Depression, Mini-Mental State Examination and the Organic mental Disorder Scale (OMDS). A statistically significant enhancement of MAO-B activity could be observed in DAT patients and in PD patients, whereas the MID group showed a mean activity similar to that of the control group and the group with other organic CNS disorders. In DAT patients the degree of dementia in the OMDS test and the enhancement of MAO activity were positively correlated, but PD did not show such a correlation. It is concluded that the increase of MAO activity in PD and in DAT might be due to a disease-related enhanced affinity to oxygen and to such oxygen-derived radicals as superoxide or hydroxyl radicals. However, a possible drug-induced enhancement of MAO activity in PD cannot be excluded. Furthermore, the MAO-B activity values in platelets of individual patients or controls are not indicative of diagnosis or prognosis of any of these diseases and are of no disease-related specificity.
将年龄和性别匹配的对照组血小板中的单胺氧化酶 - B（MAO - B）活性与几组患有非家族性阿尔茨海默病型痴呆（DAT）、帕金森病（PD）、多发性梗死性痴呆（MID）、这三种疾病的混合类型以及一组其他中枢神经系统（CNS）器质性疾病的住院患者进行了比较。所有患者都接受了多项心理测量测试，包括桑多兹临床评估 - 老年量表、汉密尔顿抑郁评定量表、简易精神状态检查和器质性精神障碍量表（OMDS）。在DAT患者和PD患者中可观察到MAO - B活性有统计学意义的增强，而MID组的平均活性与对照组及其他中枢神经系统器质性疾病组相似。在DAT患者中，OMDS测试中的痴呆程度与MAO活性增强呈正相关，但PD未显示出这种相关性。得出的结论是，PD和DAT中MAO活性的增加可能是由于疾病相关的对氧以及超氧化物或羟基自由基等氧衍生自由基的亲和力增强所致。然而，不能排除PD中MAO活性可能由药物引起增强的情况。此外，个体患者或对照组血小板中的MAO - B活性值不能指示这些疾病中任何一种的诊断或预后，且不具有疾病相关特异性。
