Götz M E, Fischer P, Gsell W, Riederer P, Streifler M, Simanyi M, Müller F, Danielczyk W
Department of Psychiatry, University of Würzburg, Germany.
Dement Geriatr Cogn Disord. 1998 Mar-Apr;9(2):74-7. doi: 10.1159/000017026.
Platelet monoamine oxidase B (MAO-B) activity has been found to increase significantly in demented patients. For the first time, a 4-year follow-up of platelet MAO-B activity and Mini-Mental State (MMS) was performed in patients with probable dementia of the Alzheimer type (DAT) and age-matched controls. MAO-B activity of DAT patients increased significantly 2 years after the beginning of the study as compared with controls and remained significantly higher for the entire period of the examinations (p < 0.0001). The decrease of the MMS scores did not correlate with the time course of the increase of platelet MAO-B activity (Spearman rank correlation test). The decline of the MMS scores of DAT patients preceded the elevation of MAO-B activity. Since degenerative processes in brain areas which are responsible for cognitive function and are reflected by the MMS scores rather affect cerebral cholinergic than monoaminergic neurotransmitter systems, degeneration of the latter at late stages of DAT might be reflected by increased platelet MAO-B activity.
已发现痴呆患者的血小板单胺氧化酶B（MAO-B）活性显著增加。首次对可能患有阿尔茨海默型痴呆（DAT）的患者和年龄匹配的对照组进行了为期4年的血小板MAO-B活性和简易精神状态检查（MMS）随访。与对照组相比，研究开始2年后，DAT患者的MAO-B活性显著增加，并且在整个检查期间一直显著高于对照组（p < 0.0001）。MMS评分的降低与血小板MAO-B活性增加的时间进程无关（Spearman等级相关检验）。DAT患者MMS评分的下降先于MAO-B活性的升高。由于负责认知功能且由MMS评分反映的脑区的退行性过程对脑胆碱能神经递质系统的影响大于单胺能神经递质系统，DAT晚期后者的退化可能通过血小板MAO-B活性增加得以体现。
