肥胖相关的肌肉质量差：流行率及与年龄、性别和体重指数的关联。
Obesity-associated poor muscle quality: prevalence and association with age, sex, and body mass index.
机构信息
Department of Systems Biology, School of Medicine, University of Alcalá, Ctra Barcelona, Km, 33 600 28871, Alcalá de Henares, Spain.
Human Performance Lab, Schulthess Clinic, Zurich, Switzerland.
出版信息
BMC Musculoskelet Disord. 2020 Mar 31;21(1):200. doi: 10.1186/s12891-020-03228-y.
BACKGROUND
Muscle quality (i.e., the expression of muscle function per unit of muscle mass) has been proposed as a clinically-relevant measure to detect individuals at risk of functional incapacity. Individuals with obesity might be at an increased risk of having poor muscle quality. Thus, we aimed to analyze the prevalence of poor muscle quality in obese individuals, to determine associated variables, and to provide normative values for this population.
METHODS
203 individuals with obesity (103 women, age: 18-75 years, body mass index (BMI): 35-64 kg·m) participated in this cross-sectional study. Their muscle strength (handgrip dynamometry), muscle power (sit-to-stand test) and muscle mass (bioelectrical impedance analysis) were measured, and muscle quality (strength/power to muscle mass ratio) was compared with reference values obtained in young healthy individuals. Muscle quality was individually categorized as normal, low or poor based on specific muscle strength and power (i.e., strength and power per unit of muscle mass, respectively). Sex and age-specific normative values of specific muscle strength and power were computed for the whole cohort.
RESULTS
Age and being a woman were inversely associated with specific muscle strength, with age being also inversely associated with specific muscle power. A small proportion of participants (6%) presented with an impaired (i.e., low/poor) specific muscle power while most of them (96%) had impaired specific muscle strength. Eventually, 84% of the participants were deemed to have poor muscle quality. Being a woman (odds ratio [OR]: 18.09, 95% confidence intervals [CI]: 4.07-80.38), age (OR: 1.06, 95%CI: 1.03-1.10) and BMI (OR: 1.22, 95%CI: 1.07-1.38) were independently associated with a higher risk of poor muscle quality in adjusted analyses.
CONCLUSIONS
These findings show a high prevalence of poor muscle quality among individuals with obesity, with age, sex and BMI being independent predictors.
背景
肌肉质量（即单位肌肉质量所表达的肌肉功能）已被提出作为一种临床相关的测量方法，用于检测功能能力受损的个体。肥胖者可能面临肌肉质量差的风险增加。因此，我们旨在分析肥胖个体中肌肉质量差的患病率，确定相关变量，并为该人群提供正常参考值。
方法
本横断面研究纳入了 203 名肥胖个体（103 名女性，年龄 18-75 岁，体重指数（BMI）35-64kg·m）。测量了他们的肌肉力量（握力测力计）、肌肉力量（从坐姿到站起测试）和肌肉质量（生物电阻抗分析），并将肌肉质量（力量/功率与肌肉质量的比值）与年轻健康个体的参考值进行比较。根据特定的肌肉力量和功率（即单位肌肉质量的力量和功率），将肌肉质量单独分类为正常、低或差。计算了整个队列的特定肌肉力量和功率的性别和年龄特异性正常参考值。
结果
年龄和女性是特定肌肉力量的负相关因素，而年龄也是特定肌肉力量的负相关因素。只有一小部分参与者（6%）的特定肌肉力量受损（即低/差），而大多数参与者（96%）的特定肌肉力量受损。最终，84%的参与者被认为肌肉质量差。女性（比值比[OR]：18.09，95%置信区间[CI]：4.07-80.38）、年龄（OR：1.06，95%CI：1.03-1.10）和 BMI（OR：1.22，95%CI：1.07-1.38）在调整分析中与肌肉质量差的高风险独立相关。
结论
这些发现表明肥胖个体中肌肉质量差的患病率较高，年龄、性别和 BMI 是独立的预测因素。
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