多形性胶质母细胞瘤的乳酸水平
Lactate levels with glioblastoma multiforme.
作者信息
Kahlon Arunpreet Singh, Alexander Mariam, Kahlon Arundeep, Wright Jonathan
机构信息
Departments of Medicine (A. S. Kahlon, Alexander, A. Kahlon) and Hematology/Oncology (Wright), State University New York-Upstate Medical University, Syracuse, New York.
出版信息
Proc (Bayl Univ Med Cent). 2016 Jul;29(3):313-4. doi: 10.1080/08998280.2016.11929449.
Abstract
A 37-year-old woman with known glioblastoma multiforme was admitted for treatment of new deep vein thrombosis. Anion gap and plasma lactate levels were found to be elevated. Magnetic resonance imaging of the brain showed a stable, advanced glioblastoma multiforme. All causes of lactic acidosis, including infections and medications, were ruled out. Aggressive tumors have been shown to produce lactate levels in minute quantities in their microenvironment, which helps them metastasize and evade immune response and even radiation.
摘要
一名患有多形性胶质母细胞瘤的37岁女性因新发深静脉血栓形成入院治疗。发现阴离子间隙和血浆乳酸水平升高。脑部磁共振成像显示多形性胶质母细胞瘤处于稳定的晚期阶段。排除了包括感染和药物在内的所有导致乳酸性酸中毒的原因。研究表明，侵袭性肿瘤在其微环境中会产生微量乳酸，这有助于它们转移、逃避免疫反应甚至辐射。
相似文献
1
Lactate levels with glioblastoma multiforme.多形性胶质母细胞瘤的乳酸水平
Proc (Bayl Univ Med Cent). 2016 Jul;29(3):313-4. doi: 10.1080/08998280.2016.11929449.
2
Low sensitivity of anion gap to detect clinically significant lactic acidosis in the emergency department.急诊科中阴离子间隙检测临床显著乳酸酸中毒的敏感性较低。
Clin Biochem. 2017 Dec;50(18):1164-1167. doi: 10.1016/j.clinbiochem.2017.07.008. Epub 2017 Jul 20.
3
High anion gap metabolic acidosis induced by cumulation of ketones, L- and D-lactate, 5-oxoproline and acute renal failure.由酮体、L-和D-乳酸、5-氧脯氨酸累积及急性肾衰竭引起的高阴离子间隙代谢性酸中毒。
Acta Clin Belg. 2018 Aug;73(4):313-316. doi: 10.1080/17843286.2017.1358504. Epub 2017 Jul 27.
4
Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis.代谢性酸中毒患者中通常与三羧酸循环相关的循环阴离子。
Crit Care. 2005 Oct 5;9(5):R591-5. doi: 10.1186/cc3806. Epub 2005 Sep 13.
5
Glioblastoma multiforme and cerebral cavernous malformations: intersection of pathophysiologic pathways.多形性胶质母细胞瘤和脑海绵状血管畸形：病理生理途径的交集。
J Clin Neurosci. 2012 Jun;19(6):884-6. doi: 10.1016/j.jocn.2011.07.017. Epub 2011 Nov 17.
6
Long-term survival and complete response of a patient with recurrent diffuse intrinsic brain stem glioblastoma multiforme.
Integr Cancer Ther. 2004 Sep;3(3):257-61. doi: 10.1177/1534735404267748.
7
Evaluation of the lactate-to-N-acetyl-aspartate ratio defined with magnetic resonance spectroscopic imaging before radiation therapy as a new predictive marker of the site of relapse in patients with glioblastoma multiforme.评估放疗前磁共振波谱成像定义的乳酸/乙酰天门冬氨酸比值作为多形性胶质母细胞瘤患者复发部位的新预测标志物。
Int J Radiat Oncol Biol Phys. 2014 Oct 1;90(2):385-93. doi: 10.1016/j.ijrobp.2014.06.009. Epub 2014 Aug 4.
8
Serum anion gap in the differential diagnosis of metabolic acidosis in critically ill newborns.血清阴离子间隙在危重新生儿代谢性酸中毒鉴别诊断中的应用
J Pediatr. 1999 Dec;135(6):751-5. doi: 10.1016/s0022-3476(99)70096-x.
9
CXCR4 expression is elevated in glioblastoma multiforme and correlates with an increase in intensity and extent of peritumoral T2-weighted magnetic resonance imaging signal abnormalities.CXCR4在多形性胶质母细胞瘤中表达升高，且与肿瘤周围T2加权磁共振成像信号异常的强度和范围增加相关。
Neurosurgery. 2008 Sep;63(3):560-9; discussion 569-70. doi: 10.1227/01.NEU.0000324896.26088.EF.
10
Infratemporal and intraorbital metastasis of the glioblastoma multiforme. A case report.多形性胶质母细胞瘤的颞下和眶内转移。病例报告。
Neurochirurgie. 2004 Jun;50(2-3 Pt 1):101-4.
引用本文的文献
1
Unravelling the Glioblastoma Tumour Microenvironment: Can Aptamer Targeted Delivery Become Successful in Treating Brain Cancers?解析胶质母细胞瘤肿瘤微环境：适体靶向递送能否成功用于治疗脑癌？
Cancers (Basel). 2023 Sep 1;15(17):4376. doi: 10.3390/cancers15174376.
2
Deciphering immune microenvironment and cell evasion mechanisms in human gliomas.解析人类胶质瘤中的免疫微环境和细胞逃逸机制。
Front Oncol. 2023 May 19;13:1135430. doi: 10.3389/fonc.2023.1135430. eCollection 2023.
3
Metabolomics in High Grade Gliomas.高级别胶质瘤中的代谢组学
RAS Oncol Ther. 2022;3(1). doi: 10.51520/2766-2586-17. Epub 2022 Sep 30.
4
Drug Resistance in Glioblastoma: The Two Faces of Oxidative Stress.胶质母细胞瘤中的耐药性：氧化应激的两面性
Front Mol Biosci. 2021 Jan 27;7:620677. doi: 10.3389/fmolb.2020.620677. eCollection 2020.
5
Bidirectional Relation Between Parkinson's Disease and Glioblastoma Multiforme.帕金森病与多形性胶质母细胞瘤之间的双向关系
Front Neurol. 2020 Aug 20;11:898. doi: 10.3389/fneur.2020.00898. eCollection 2020.
6
Type B lactic acidosis: a rare oncological emergency.B型乳酸酸中毒：一种罕见的肿瘤急症。
BMJ Case Rep. 2020 Mar 31;13(3):e233068. doi: 10.1136/bcr-2019-233068.
7
Glioblastoma Chemoresistance: The Double Play by Microenvironment and Blood-Brain Barrier.胶质母细胞瘤化疗耐药：微环境与血脑屏障的双重作用。
Int J Mol Sci. 2018 Sep 22;19(10):2879. doi: 10.3390/ijms19102879.
8
Elucidating immunometabolic targets in glioblastoma.阐明胶质母细胞瘤中的免疫代谢靶点。
Am J Cancer Res. 2017 Oct 1;7(10):1990-1995. eCollection 2017.
本文引用的文献
1
Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma.抑制乳酸脱氢酶A通过下调胶质母细胞瘤中的瓦伯格效应来损害肿瘤进展。
Neuroreport. 2016 Jan 20;27(2):110-5. doi: 10.1097/WNR.0000000000000506.
2
The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor.乳酸脱氢酶A的调控与功能：在脑肿瘤中的治疗潜力
Brain Pathol. 2016 Jan;26(1):3-17. doi: 10.1111/bpa.12299. Epub 2015 Sep 17.
3
Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment.在小鼠中模拟肺泡软组织肉瘤发生：乳酸在肿瘤微环境中的作用。
Cancer Cell. 2014 Dec 8;26(6):851-862. doi: 10.1016/j.ccell.2014.10.003. Epub 2014 Nov 26.
4
Warburg's effect on solid tumors.瓦伯格效应与实体瘤
Saudi J Kidney Dis Transpl. 2014 Nov;25(6):1270-7. doi: 10.4103/1319-2442.144266.
5
Etiology and therapeutic approach to elevated lactate levels.乳酸水平升高的病因和治疗方法。
Mayo Clin Proc. 2013 Oct;88(10):1127-40. doi: 10.1016/j.mayocp.2013.06.012.
6
Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.mTORC1/2抑制剂对胶质母细胞瘤中PI3K-Akt-mTOR信号通路的抑制作用
Methods Mol Biol. 2012;821:349-59. doi: 10.1007/978-1-61779-430-8_22.
7
Lactate: a metabolic key player in cancer.乳酸：癌症中的代谢关键因子。
Cancer Res. 2011 Nov 15;71(22):6921-5. doi: 10.1158/0008-5472.CAN-11-1457.
8
Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release.乳酸促进肿瘤细胞的迁移运动，并抑制单核细胞的迁移和细胞因子的释放。
Int J Oncol. 2011 Aug;39(2):453-63. doi: 10.3892/ijo.2011.1055. Epub 2011 May 25.
9
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.乳酸通过内皮细胞单羧酸转运蛋白 MCT1 的内流支持 NF-κB/IL-8 通路，从而驱动肿瘤血管生成。
Cancer Res. 2011 Apr 1;71(7):2550-60. doi: 10.1158/0008-5472.CAN-10-2828. Epub 2011 Feb 7.
10
Suppression of T-cell responses by tumor metabolites.肿瘤代谢物抑制 T 细胞应答。
Cancer Immunol Immunother. 2011 Mar;60(3):425-31. doi: 10.1007/s00262-010-0967-1. Epub 2011 Jan 15.
Zotero 插件