1 Department of Dermatology and Venereology, National and Kapodistrian University of Athens, "Andreas Sygros" Hospital for Skin and Venereal Diseases, Athens, Greece
Department of Cytogenetics and Molecular Genetics, Bioiatriki, Group of Health Sciences, Athens, Greece.
Anticancer Res. 2020 Apr;40(4):2219-2223. doi: 10.21873/anticanres.14183.
To investigate the prevalence of cervico-vaginal co-infection with high-risk (HR) HPV types and other sexually transmitted pathogens (STPs) in women with anogenital warts (AGWs).
In this cross-sectional study, cervico-vaginal smears of women with AGWs were examined with real-time polymerase chain reaction for the presence of HR-HPV types and common STPs. Women with recent cervical HPV infection and general population were used for comparisons.
A total of 689 women participated in the study. Among the examined groups, higher rates of cervico-vaginal co-infection with HR-HPV types and other STPs collectively were recorded in women with AGWs (p=0.0049 and p<0.004, respectively). Within the AGWs group, cervical co-infection with HR-HPV types was detected more often in women with recurrent disease (p<0.001).
The higher rates of cervico-vaginal co-infection with HR-HPV types and common STPs in women with AGWs may affect their risk for cervical carcinogenesis and the natural course of their disease.
调查患有生殖器疣（AGW）的女性中高危（HR）HPV 型和其他性传播病原体（STP）的宫颈阴道合并感染的流行情况。
在这项横断面研究中，采用实时聚合酶链反应检测 AGW 女性宫颈阴道拭子中 HR-HPV 型和常见 STP 的存在情况。将近期宫颈 HPV 感染和普通人群的女性用于比较。
共有 689 名女性参与了这项研究。在所检查的组中，AGW 女性的宫颈阴道 HR-HPV 型和其他 STP 的合并感染率更高（p=0.0049 和 p<0.004，分别）。在 AGW 组中，复发性疾病的女性中更常检测到宫颈 HR-HPV 型合并感染（p<0.001）。
患有生殖器疣的女性中宫颈阴道合并感染 HR-HPV 型和常见 STP 的比率较高，可能会影响其宫颈癌发生的风险和疾病的自然病程。
