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带蒂或游离皮瓣的颈侧入路挽救性全喉切除术不进行咽加强:我们在 6 例患者中的初步经验。

Lateral cervical approach for salvage total laryngectomy without pharyngeal reinforcement with pedicled or free flaps: our preliminary experience in six patients.

机构信息

Humanitas University, Via Rita Levi Montalcini, 4, 20090, Pieve Emanuele, MI, Italy.

Department of Otorhinolaryngology Head and Neck Surgery, IRCCS Humanitas Clinical and Research Center, Via Alessandro Manzoni, 56, 20089, Rozzano, MI, Italy.

出版信息

Eur Arch Otorhinolaryngol. 2020 Jun;277(6):1837-1841. doi: 10.1007/s00405-020-05942-8. Epub 2020 Mar 31.

DOI:10.1007/s00405-020-05942-8
PMID:32236707
Abstract

PURPOSE

To analyze the surgical outcomes in terms of postoperative wound complications in a small case series of six patients treated with lateral cervical approach (LCA) for salvage total laryngectomy (STL) without prophylactic use of the pectoralis major myocutaneous flap (PMMF) or free flaps.

METHODS

Between September 2018 and August 2019, six patients with recurrent/residual squamous-cell carcinoma after (chemo)radiotherapy [(C)RT] underwent STL with minimally invasive LCA with the anterior myocutaneous flap (AMCF), sparing the prelaryngeal tissue. Clinical records were retrospectively reviewed.

RESULTS

Wound dehiscence and local complications were prevented in five cases. Pharyngocutaneous fistula (PCF) occurred in one case and the closure was achieved by medical dressing with spontaneous healing within 15 days. Oral intake of liquids started 2 weeks after surgery in the five patients without local complications, after 24 days in the patient with PCF.

CONCLUSION

STL through the LCA after [(C)RT] failure seems to be feasible and effective in terms of prevention of local complications as wound dehiscence and fistula. More large clinical series are needed to confirm whether the use of LCA reduced the rate of postoperative wound complications following STL without the prophylactic use of pedicled or free flaps.

摘要

目的

分析 6 例接受侧颈入路(LCA)挽救性全喉切除术(STL)的患者的术后伤口并发症的手术结果,这些患者在没有预防性使用胸大肌肌皮瓣(PMMF)或游离皮瓣的情况下接受了治疗。

方法

2018 年 9 月至 2019 年 8 月,6 例接受(放)化疗后复发/残留鳞状细胞癌的患者接受了微创 LCA 联合前肌皮瓣(AMCF)的 STL,保留了咽前组织。回顾性分析临床记录。

结果

5 例患者预防了伤口裂开和局部并发症。1 例患者发生咽皮瘘(PCF),经药物敷贴治疗,15 天内自发愈合。5 例无局部并发症的患者在术后 2 周开始经口摄入液体,PCF 患者在术后 24 天开始经口摄入液体。

结论

在(放)化疗失败后,通过 LCA 行 STL 在预防伤口裂开和瘘管等局部并发症方面似乎是可行和有效的。需要更多的大样本临床系列研究来证实,在没有预防性使用带蒂或游离皮瓣的情况下,LCA 的使用是否降低了 STL 术后伤口并发症的发生率。

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Oral Oncol. 2019 Nov;98:165-167. doi: 10.1016/j.oraloncology.2019.09.002. Epub 2019 Sep 11.
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Salvage laryngectomy following organ-preservation therapy - An evidence-based review.挽救性喉切除术联合器官保留治疗后的评估 - 基于循证医学的综述。
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Systematic review and meta-analysis of the complications of salvage total laryngectomy.挽救性全喉切除术并发症的系统评价与荟萃分析
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Preventing pharyngo-cutaneous fistula in total laryngectomy: a systematic review and meta-analysis.预防全喉切除术后咽皮瘘:系统评价和荟萃分析。
Laryngoscope. 2014 May;124(5):1150-63. doi: 10.1002/lary.24448. Epub 2013 Nov 15.
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