Yuan Zhi-Hua, Yu Xiao, Duan Ya-di, Liu Peng, Jiang Yan-Yan, Zhang Wei, Liu Bin
School of Chinese Pharmacy, Beijing University of Chinese Medicine Beijing 102488, China.
Zhongguo Zhong Yao Za Zhi. 2020 Mar;45(5):1034-1038. doi: 10.19540/j.cnki.cjcmm.20191206.201.
The study on the targets of traditional Chinese medicine is an important part of researchers using modern scientific language to clarify the mechanism of traditional Chinese medicine. However, the research on the targets of Chinese medicine is full of challenges due to the complexity of active ingredients. As a branch of systems biology, proteomics focus on specific proteins in living organisms from a holistic perspective, which significantly improves the efficiency of targets discovery and has obvious advantages in the research of targets of Chinese medicine. Based on relevant literature and different methods used in targets of Chinese medicine, proteomics can be divided into chemical proteomics, differential proteomics and quantitative proteomics. The applications of the above three methods are illustrated in this paper as well, which will provide new methods and ideas for the study of the mechanism of Chinese medicine in the future.
中药靶点研究是研究者运用现代科学语言阐释中药作用机制的重要组成部分。然而，由于活性成分的复杂性，中药靶点研究面临诸多挑战。蛋白质组学作为系统生物学的一个分支，从整体角度关注生物体中的特定蛋白质，显著提高了靶点发现的效率，在中药靶点研究中具有明显优势。基于相关文献及中药靶点研究中使用的不同方法，蛋白质组学可分为化学蛋白质组学、差异蛋白质组学和定量蛋白质组学。本文还阐述了上述三种方法的应用，这将为未来中药作用机制的研究提供新的方法和思路。
