Cardiovascular Research Centre, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Inflamm Res. 2020 Jun;69(6):549-558. doi: 10.1007/s00011-020-01341-1. Epub 2020 Apr 1.
Cannabis has been used for thousands of years in many cultures for the treatment of several ailments including pain. The benefits of cannabis are mediated largely by cannabinoids, the most prominent of which are tetrahydrocannabinol (THC) and cannabidiol (CBD). As such, THC and/or CBD have been investigated in clinical studies for the treatment of many conditions including neuropathic pain and acute or chronic inflammation. While a plethora of studies have examined the biochemical effects of purified THC and/or CBD, only a few have focused on the effects of full-spectrum cannabis plant extract. Accordingly, studies using purified THC or CBD may not accurately reflect the potential health benefits of full-spectrum cannabis extracts. Indeed, the cannabis plant produces a wide range of cannabinoids, terpenes, flavonoids, and other bioactive molecules which are likely to contribute to the different biological effects. The presence of all these bioactive molecules in cannabis extracts has garnered much attention of late especially with regard to their potential role in the treatment of neuropathic pain associated with multiple sclerosis.
Literature review was performed to further understand the effect of clinically used full-spectrum cannabis extract in patients with multiple sclerosis.
Herein, the current knowledge about the potential beneficial effects of existing products of full-spectrum cannabis extract in clinical studies involving patients with multiple sclerosis is extensively reviewed. In addition, the possible adverse effects associated with cannabis use is discussed along with how the method of extraction and the delivery mechanisms of different cannabis extracts contribute to the pharmacokinetic and biological effects of full-spectrum cannabis extracts.Herein, the current knowledge about the potential beneficial effects of existing products of full-spectrum cannabis extract in clinical studies involving patients with multiple sclerosis is extensively reviewed. In addition, the possible adverse effects associated with cannabis use is discussed along with how the method of extraction and the delivery mechanisms of different cannabis extracts contribute to the pharmacokinetic and biological effects of full-spectrum cannabis extracts.
大麻在许多文化中被使用了数千年，用于治疗包括疼痛在内的多种疾病。大麻的益处主要通过大麻素介导，其中最突出的是四氢大麻酚（THC）和大麻二酚（CBD）。因此，THC 和/或 CBD 已在临床研究中用于治疗许多疾病，包括神经病理性疼痛和急性或慢性炎症。虽然有大量研究检查了纯化 THC 和/或 CBD 的生化作用，但只有少数研究集中在全谱大麻植物提取物的作用上。因此，使用纯化 THC 或 CBD 的研究可能无法准确反映全谱大麻提取物的潜在健康益处。事实上，大麻植物产生了广泛的大麻素、萜烯、类黄酮和其他生物活性分子，这些分子可能有助于不同的生物学作用。大麻提取物中所有这些生物活性分子的存在最近引起了广泛关注，尤其是它们在治疗多发性硬化症相关的神经病理性疼痛方面的潜在作用。
进行文献综述，以进一步了解全谱大麻提取物在多发性硬化症患者中的临床应用效果。
本文广泛综述了现有全谱大麻提取物产品在涉及多发性硬化症患者的临床研究中的潜在有益作用的现有知识。此外，还讨论了与大麻使用相关的可能不良反应，以及不同大麻提取物的提取方法和输送机制如何影响全谱大麻提取物的药代动力学和生物学作用。本文广泛综述了现有全谱大麻提取物产品在涉及多发性硬化症患者的临床研究中的潜在有益作用的现有知识。此外，还讨论了与大麻使用相关的可能不良反应，以及不同大麻提取物的提取方法和输送机制如何影响全谱大麻提取物的药代动力学和生物学作用。
