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进食状态下脂质燃料可利用性变化与组织果糖-2,6-二磷酸浓度及丙酮酸脱氢酶复合体活性之间的关系。

The relationship between changes in lipid fuel availability and tissue fructose 2,6-bisphosphate concentrations and pyruvate dehydrogenase complex activities in the fed state.

作者信息

French T J, Goode A W, Holness M J, MacLennan P A, Sugden M C

机构信息

Surgical Unit, London Hospital, Whitechapel, U.K.

出版信息

Biochem J. 1988 Dec 15;256(3):935-9. doi: 10.1042/bj2560935.

DOI:10.1042/bj2560935
PMID:3223963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1135506/
Abstract

An elevated concentration of non-esterified fatty acids in the fed state elicited inhibition of cardiac, but not hepatic, pyruvate dehydrogenase complex (PDH). There was a modest decline in fructose 2,6-bisphosphate (Fru-2,6-P2) concentration in heart, and, to a lesser extent, in liver. Surgical stress decreased PDH activities and Fru-2,6-P2 concentrations in both heart and liver. Only the former response was abolished if postoperative lipolysis was inhibited. Surgery also decreased the [Fru-2,6-P2] in gastrocnemius: this response was abolished if lipolysis was inhibited.

摘要

进食状态下非酯化脂肪酸浓度升高会抑制心脏丙酮酸脱氢酶复合体（PDH）的活性，但对肝脏的该复合体无抑制作用。心脏中果糖2,6 -二磷酸（Fru - 2,6 - P2）的浓度略有下降，肝脏中的下降幅度较小。手术应激会降低心脏和肝脏中PDH的活性以及Fru - 2,6 - P2的浓度。如果术后脂解作用受到抑制，只有前者的反应会被消除。手术还会降低腓肠肌中Fru - 2,6 - P2的浓度：如果脂解作用受到抑制，这种反应会被消除。

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本文引用的文献

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The effects of starvation and refeeding on carbohydrate and lipid metabolism in vivo and in the perfused rat liver. The relationship between fatty acid oxidation and esterification in the regulation of ketogenesis.饥饿和再喂养对大鼠体内及灌注肝脏中碳水化合物和脂质代谢的影响。脂肪酸氧化与酯化在生酮调节中的关系。
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