进食状态下脂质燃料可利用性变化与组织果糖-2,6-二磷酸浓度及丙酮酸脱氢酶复合体活性之间的关系。
The relationship between changes in lipid fuel availability and tissue fructose 2,6-bisphosphate concentrations and pyruvate dehydrogenase complex activities in the fed state.
作者信息
French T J, Goode A W, Holness M J, MacLennan P A, Sugden M C
机构信息
Surgical Unit, London Hospital, Whitechapel, U.K.
出版信息
Biochem J. 1988 Dec 15;256(3):935-9. doi: 10.1042/bj2560935.
Abstract
An elevated concentration of non-esterified fatty acids in the fed state elicited inhibition of cardiac, but not hepatic, pyruvate dehydrogenase complex (PDH). There was a modest decline in fructose 2,6-bisphosphate (Fru-2,6-P2) concentration in heart, and, to a lesser extent, in liver. Surgical stress decreased PDH activities and Fru-2,6-P2 concentrations in both heart and liver. Only the former response was abolished if postoperative lipolysis was inhibited. Surgery also decreased the [Fru-2,6-P2] in gastrocnemius: this response was abolished if lipolysis was inhibited.
摘要
进食状态下非酯化脂肪酸浓度升高会抑制心脏丙酮酸脱氢酶复合体（PDH）的活性，但对肝脏的该复合体无抑制作用。心脏中果糖2,6 -二磷酸（Fru - 2,6 - P2）的浓度略有下降，肝脏中的下降幅度较小。手术应激会降低心脏和肝脏中PDH的活性以及Fru - 2,6 - P2的浓度。如果术后脂解作用受到抑制，只有前者的反应会被消除。手术还会降低腓肠肌中Fru - 2,6 - P2的浓度：如果脂解作用受到抑制，这种反应会被消除。
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