Division of Biomedical Informatics and Personalized Medicine, School of Medicine University of Colorado, Anschutz Medical Campus, Aurora, CO, United States of America.
Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, United States of America.
PLoS One. 2020 Apr 2;15(4):e0231013. doi: 10.1371/journal.pone.0231013. eCollection 2020.
Biomarkers of chronic inflammation (such as C-reactive protein) have long been associated with cardiovascular disease and mortality; however, biomarkers involved in antiviral cytokine induction and adaptive immune system activation remain largely unexamined. We hypothesized the cytokine interferon gamma inducible protein 10 (IP-10) would be associated with clinical and subclinical cardiovascular disease and all-cause mortality in African Americans. We assessed these associations in the Jackson Heart Study (JHS) cohort and the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. There was a modest association of IP-10 with higher odds of left ventricular hypertrophy (OR = 1.20 (95% confidence interval (CI) 1.03, 1.41) per standard deviation (SD) higher natural log-transformed IP-10 in JHS). We did not observe associations with ankle brachial index, intima-media thickness, or arterial calcification. Each SD higher increment of ln-transformed IP-10 concentration was associated with incident heart failure (hazard ratio (HR) 1.26; 95% CI 1.11, 1.42, p = 4x10-4) in JHS, and with overall mortality in both JHS (HR 1.12 per SD, 95% CI 1.03, 1.21, p = 7.5x10-3) and REGARDS (HR 1.31 per SD, 95% CI 1.10, 1.55, p = 2.0 x 10-3), adjusting for cardiovascular risk factors and C-reactive protein. However, we found no association between IP-10 and stroke or coronary heart disease. These results suggest a role of IP-10 in heart failure and mortality risk independent of C-reactive protein. Further research is needed to investigate how the body's response to chronic viral infection may mediate heart failure and overall mortality risk in African Americans.
慢性炎症生物标志物（如 C 反应蛋白）长期以来一直与心血管疾病和死亡率相关；然而，涉及抗病毒细胞因子诱导和适应性免疫系统激活的生物标志物在很大程度上仍未得到研究。我们假设细胞因子干扰素γ诱导蛋白 10（IP-10）与非裔美国人的临床和亚临床心血管疾病以及全因死亡率相关。我们在 Jackson 心脏研究（JHS）队列和地理和种族差异中风原因研究（REGARDS）中评估了这些关联。IP-10 与左心室肥厚的更高几率呈适度相关（OR = 1.20（95%置信区间（CI）1.03，1.41），每标准偏差（SD）更高的自然对数转换 IP-10 在 JHS 中）。我们没有观察到与踝臂指数、内膜中层厚度或动脉钙化的关联。ln 转换的 IP-10 浓度每增加一个 SD，与 JHS 中的心力衰竭事件（风险比（HR）1.26；95%CI 1.11，1.42，p = 4x10-4）相关，与 JHS 中的全因死亡率（HR 1.12 每 SD，95%CI 1.03，1.21，p = 7.5x10-3）和 REGARDS（HR 1.31 每 SD，95%CI 1.10，1.55，p = 2.0 x 10-3）相关，调整了心血管危险因素和 C 反应蛋白。然而，我们没有发现 IP-10 与中风或冠心病之间的关联。这些结果表明，IP-10 在心力衰竭和死亡率风险中独立于 C 反应蛋白发挥作用。需要进一步研究来研究人体对慢性病毒感染的反应如何介导非裔美国人的心力衰竭和总体死亡率风险。
