College of Food Science and Engineering, Ocean University of China, Qingdao, 266003 Shandong, People's Republic of China.
Istituto di Scienze e Tecnologie Chimiche "Giulio Natta", CNR, sede di Via Mario Bianco, 9, 20131, Milano, Italy.
Carbohydr Polym. 2020 Jun 1;237:116116. doi: 10.1016/j.carbpol.2020.116116. Epub 2020 Mar 4.
In order to identify an appropriate substitute for antibiotic use in livestock production, this study investigates the fermentation of guar gum and its low molecular weight hydrolyzed derivatives (GMLP-1, 1-10 kDa; GMLP-2, < 1 kDa) in pig fecal cultures and the associated effects on the intestinal microbiota. Both the non-hydrolyzed guar gum and GMLP were quickly utilized by fecal microbiota. GMLP-2 showed the most rapid SCFA-producing activity and produced higher concentrations of lactate, acetate, and propionate. However, GMLP-1 showed the highest yield of total SCFAs and butyrate. Both the guar gum and GMLP groups improved the abundance of Clostridium sensu stricto 1 and Bifidobacterium, but the most significant enhancement was observed with GMLP-1. This study showed that by associating with its chemical structure, GMLP-1 can be utilized to direct a targeted promotion of the intestinal microbiota and may offer the most favorable effects in livestock production.
为了在畜牧业生产中寻找抗生素的替代物，本研究调查了瓜尔胶及其低分子量水解衍生物（GMLP-1，1-10 kDa；GMLP-2，<1 kDa）在猪粪便培养物中的发酵情况，以及其对肠道微生物群的相关影响。非水解瓜尔胶和 GMLP 都被粪便微生物群迅速利用。GMLP-2 表现出最快的产生 SCFA 的活性，并产生更高浓度的乳酸、乙酸和丙酸。然而，GMLP-1 表现出最高的总 SCFA 和丁酸产量。瓜尔胶组和 GMLP 组都增加了严格梭菌 1 和双歧杆菌的丰度，但 GMLP-1 的增加最为显著。本研究表明，通过与化学结构相关联，GMLP-1 可用于定向促进肠道微生物群，并可能在畜牧业生产中产生最有利的影响。
