Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Department of Clinical Medicine, Aarhus University Hospital, 8200 N Aarhus, Denmark.
Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Department of Clinical Medicine, Aarhus University Hospital, 8200 N Aarhus, Denmark.
Cell. 2020 Apr 2;181(1):63-80. doi: 10.1016/j.cell.2020.03.007.
Autoimmune diseases are a result of the immune system being misdirected toward its host and have major and increasing unmet clinical needs. In general, present therapies are broadly acting and non-disease specific; consequently, they are associated with numerous side effects. Precise and early intervention strategies are urgently needed. We highlight the challenges, progress, and prospects in achieving these goals.
自身免疫性疾病是免疫系统错误攻击自身的结果，存在重大且日益未满足的临床需求。一般来说，目前的治疗方法作用广泛且非针对特定疾病；因此，它们会引起许多副作用。迫切需要精确和早期的干预策略。我们强调了在实现这些目标方面面临的挑战、取得的进展和前景。
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