NANO-VAC Research Group, Department of Chemistry and Pharmaceutical Technology, University of Navarra, Spain.
NANO-VAC Research Group, Department of Chemistry and Pharmaceutical Technology, University of Navarra, Spain.
Int J Pharm. 2020 May 15;581:119289. doi: 10.1016/j.ijpharm.2020.119289. Epub 2020 Mar 31.
Proteins represent a group of biopolymers with interesting properties to be employed as raw materials in the preparation of nanoparticles for drug delivery purposes. Due to the inherent properties of proteins (i.e., biodegradability, amphiphilic properties, etc.) the resulting nanoparticles can be considered as versatility platforms for a variety of applications. Moreover, some proteins possess a GRAS (Generally Recognized as Safe) status or are considered as excipients by different Regulatory Agencies. As result of this, the resulting nanoparticles and potential translation to clinic would be facilitated, compared to other materials (i.e., polymers). This review is focused on the main proteins employed in the preparation of nanoparticles as well as the procedures permitting their transformation into nanoparticles able of accommodating a high variety of bioactive compounds and drugs. Moreover, the review also provides examples of application of nanoparticles prepared from albumins, globulins, prolamins or macromolecules derived from proteins.
蛋白质是一组具有有趣性质的生物聚合物，可用作药物递送目的的纳米颗粒制备的原料。由于蛋白质的固有特性（即生物降解性、两亲性等），所得纳米颗粒可被视为多种应用的多功能平台。此外，一些蛋白质具有 GRAS（一般认为安全）地位，或被不同的监管机构视为赋形剂。因此，与其他材料（如聚合物）相比，所得纳米颗粒及其向临床的潜在转化将更加容易。本综述重点介绍了用于制备纳米颗粒的主要蛋白质以及允许将其转化为能够容纳多种生物活性化合物和药物的纳米颗粒的方法。此外，该综述还提供了来自白蛋白、球蛋白、醇溶蛋白或蛋白质衍生的大分子的纳米颗粒的应用示例。
