长期补充白藜芦醇可改善绝经后妇女的疼痛感知、更年期症状和整体幸福感：来自为期 24 个月的随机、对照、交叉试验的结果。

Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial.

机构信息

University of Newcastle, School of Biomedical Sciences and Pharmacy, Callaghan, NSW, Australia.

University of Southern Queensland, Institute for Resilient Regions, Springfield Central, QLD, Australia.

出版信息

Menopause. 2020 Aug 31;28(1):40-49. doi: 10.1097/GME.0000000000001643.

DOI:10.1097/GME.0000000000001643

PMID:32881835

Abstract

OBJECTIVE

Following concerns about hormone therapy, postmenopausal women need alternative options to manage menopause-related symptoms and improve their well-being. A 14-week pilot study has shown that supplementation with resveratrol, a phytoestrogen with circulatory benefits, can improve aspects of well-being including chronic pain, which is a common complaint in postmenopausal women. We aimed to confirm these benefits in a larger, long-term study.

METHODS

The Resveratrol for Healthy Ageing in Women study, a 24-month randomized, double-blind, placebo-controlled, two-period crossover intervention trial of resveratrol supplementation (75 mg BID) was conducted in 125 healthy postmenopausal women to evaluate effects on cognitive performance (results published elsewhere). Aspects of well-being including pain perception, mood and depressive symptoms, menopausal symptoms, sleep quality, and quality of life were assessed with questionnaires as secondary outcomes of the study. Cerebrovascular responsiveness to hypercapnia was measured as a surrogate marker of cerebrovascular function.

RESULTS

Resveratrol supplementation reduced composite pain score (P < 0.001), especially in overweight individuals; this was associated with improvements in cerebrovascular responsiveness to hypercapnia (R = -0.329, P = 0.014). Somatic menopausal symptoms (P = 0.024) and general well-being (P = 0.010) were also improved after resveratrol supplementation.

CONCLUSIONS

These results confirm the pilot study finding that resveratrol supplementation can reduce chronic pain in age-related osteoarthritis and improve menopause-related quality of life in postmenopausal women. These improvements are sustained by supplementation for at least 12 months and are associated with enhancement of circulatory function.

CLINICAL TRIAL REGISTRATION

ACTRN12616000679482p.

摘要

目的

由于对激素疗法的担忧，绝经后女性需要替代方案来管理与绝经相关的症状并改善她们的健康状况。一项为期 14 周的试点研究表明，补充白藜芦醇（一种具有循环益处的植物雌激素）可以改善健康状况的各个方面，包括绝经后妇女常见的慢性疼痛。我们旨在通过一项更大、长期的研究来证实这些益处。

方法

在 125 名健康绝经后女性中进行了为期 24 个月的随机、双盲、安慰剂对照、两期交叉干预试验，以评估白藜芦醇补充剂（75mg BID）的效果（结果已在其他地方发表）。使用问卷评估健康状况的各个方面，包括疼痛感知、情绪和抑郁症状、绝经症状、睡眠质量和生活质量，作为研究的次要结果。脑血管对高碳酸血症的反应性作为脑血管功能的替代标志物进行测量。