非编码RNA和RNA结合蛋白在有丝分裂器形成中的新兴作用
The Emerging Role of ncRNAs and RNA-Binding Proteins in Mitotic Apparatus Formation.
作者信息
Ito Kei K, Watanabe Koki, Kitagawa Daiju
机构信息
Department of Physiological Chemistry, Graduate School of Pharmaceutical Science, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan.
出版信息
Noncoding RNA. 2020 Mar 20;6(1):13. doi: 10.3390/ncrna6010013.
Mounting experimental evidence shows that non-coding RNAs (ncRNAs) serve a wide variety of biological functions. Recent studies suggest that a part of ncRNAs are critically important for supporting the structure of subcellular architectures. Here, we summarize the current literature demonstrating the role of ncRNAs and RNA-binding proteins in regulating the assembly of mitotic apparatus, especially focusing on centrosomes, kinetochores, and mitotic spindles.
越来越多的实验证据表明，非编码RNA（ncRNA）具有多种生物学功能。最近的研究表明，一部分ncRNA对于维持亚细胞结构的稳定性至关重要。在这里，我们总结了当前的文献，这些文献展示了ncRNA和RNA结合蛋白在调节有丝分裂装置组装中的作用，特别是着重于中心体、动粒和有丝分裂纺锤体。
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