Boston Keratoprosthesis Laboratory, Massachusetts Eye and Ear, Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States.
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.
J Biophotonics. 2020 Jul;13(7):e202000031. doi: 10.1002/jbio.202000031. Epub 2020 Apr 20.
Artificial cornea is an effective treatment of corneal blindness. Yet, intraocular pressure (IOP) measurements for glaucoma monitoring remain an urgent unmet need. Here, we present the integration of a fiber-optic Fabry-Perot pressure sensor with an FDA-approved keratoprosthesis for real-time IOP measurements using a novel strategy based on optical-path self-alignment with micromagnets. Additionally, an alternative noncontact sensor-interrogation approach is demonstrated using a bench-top optical coherence tomography system. We show stable pressure readings with low baseline drift (<2.8 mm Hg) for >4.5 years in vitro and efficacy in IOP interrogation in vivo using fiber-optic self-alignment, with good initial agreement with the actual IOP. Subsequently, IOP drift in vivo was due to retroprosthetic membrane (RPM) formation on the sensor secondary to surgical inflammation (more severe in the current pro-fibrotic rabbit model). This study paves the way for clinical adaptation of optical pressure sensors with ocular implants, highlighting the importance of controlling RPM in clinical adaptation.
人工角膜是治疗角膜盲的有效方法。然而，用于青光眼监测的眼内压（IOP）测量仍然是一个迫切未满足的需求。在这里，我们提出了将光纤法布里-珀罗压力传感器与经美国食品和药物管理局批准的角膜假体集成，使用基于光学路径自对准和微磁铁的新策略来进行实时 IOP 测量。此外，还展示了一种使用台式光学相干断层扫描系统的替代非接触式传感器询问方法。我们在体外展示了稳定的压力读数，其基线漂移低（<2.8mmHg），持续超过 4.5 年，并且使用光纤自对准在体内进行 IOP 询问有效，与实际 IOP 具有良好的初始一致性。随后，由于传感器上的后巩膜膜（RPM）形成导致眼内压漂移，这是手术炎症引起的（在当前的促纤维化兔模型中更为严重）。这项研究为眼科植入物的光学压力传感器的临床应用铺平了道路，强调了在临床应用中控制 RPM 的重要性。
