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从（林德利）中分离出的成分的抗氧化和抗炎活性。 （注：原文中“(Lindl.)”前面的植物名称缺失，导致译文不太完整准确）

Antioxidant and anti-inflammatory activity of constituents isolated from (Lindl.).

作者信息

Lei Hui, Zou Shunmei, Lin Jiafu, Zhai Longfei, Zhang Yifeng, Fu Xiujuan, Chen Siwei, Niu Hong, Liu Feifei, Wu Chunlian, Zhang Dan

机构信息

School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.

School of Pharmacy, Chengdu University, Chengdu, Sichuan, China.

出版信息

Front Chem. 2022 Oct 4;10:988459. doi: 10.3389/fchem.2022.988459. eCollection 2022.

DOI:10.3389/fchem.2022.988459
PMID:36267656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9577000/
Abstract

(Lindl.) have long been used as herbal tea and a traditional herbal medicine to treat Alzheimer's disease (AD). In the current study, nineteen compounds (), including two new vitamin E homologues (), one new sesquiterpene (), and two new dendrobines (, ), were isolated and identified from stems of . Their structures were elucidated on the basis of NMR, C NMR calculation, and DP4 probability analyses. The absolute configurations of new compounds were determined by electronic circular dichroism (ECD) data analysis. Antioxidant, anti-inflammatory, and cytotoxic activities of isolated compounds were evaluated. Among them, compound demonstrated significant antioxidant activity compared with ascorbic acid (VC), while compounds and also exhibited an equal effect to positive control cisplatin. This study on the biological activity of the new vitamin E homologues from may indicate its potential application in the pharmaceutical and food industries.

摘要

（林德尔）长期以来一直被用作草药茶和传统草药来治疗阿尔茨海默病（AD）。在当前研究中，从[植物名称]的茎中分离并鉴定出19种化合物（），包括两种新的维生素E同系物（）、一种新的倍半萜（）和两种新的石蒜碱（，）。它们的结构通过核磁共振（NMR）、碳核磁共振（C NMR）计算和DP4概率分析得以阐明。新化合物的绝对构型通过电子圆二色性（ECD）数据分析确定。对分离出的化合物的抗氧化、抗炎和细胞毒性活性进行了评估。其中，化合物与抗坏血酸（VC）相比表现出显著的抗氧化活性，而化合物和对阳性对照顺铂也表现出同等效果。这项对来自[植物名称]的新维生素E同系物的生物活性研究可能表明其在制药和食品工业中的潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/3bc724de8d26/FCHEM_fchem-2022-988459_wc_sch1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/b33f8e091045/fchem-10-988459-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/e35c7aa991b8/fchem-10-988459-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/e8f8f0131ef5/fchem-10-988459-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/f8c818658343/fchem-10-988459-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/1fcc93ebffce/fchem-10-988459-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/e3d5c395e00a/fchem-10-988459-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/da6495387788/fchem-10-988459-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/3bc724de8d26/FCHEM_fchem-2022-988459_wc_sch1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/b33f8e091045/fchem-10-988459-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/e35c7aa991b8/fchem-10-988459-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/e8f8f0131ef5/fchem-10-988459-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/f8c818658343/fchem-10-988459-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/1fcc93ebffce/fchem-10-988459-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/e3d5c395e00a/fchem-10-988459-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/da6495387788/fchem-10-988459-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5666/9577000/3bc724de8d26/FCHEM_fchem-2022-988459_wc_sch1.jpg

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