Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
NUTRIM School for Nutrition and Translational Metabolism, Maastricht University, Maastricht, The Netherlands.
Sci Rep. 2020 Apr 6;10(1):5963. doi: 10.1038/s41598-020-62918-8.
This study investigated whether there are differences in the composition of the cutaneous microbiome of the unaffected skin between patients with pressure ulcers compared with those without pressure ulcers. The cutaneous microbiome of the unaffected skin of 15 patients with sacral pressure ulcers compared to 15 patients without pressure ulcers was analysed. It demonstrated that the inter-individual variation in skin microbiota of patients with pressure ulcers was significantly higher (P = 0.01). The abundance of 23 species was significantly different with Staphylococcus aureus and unclassified Enterococcus the most abundant species in patients with pressure ulcers. Random Forest models showed that eight species were associated with pressure ulcers occurrence in 81% of the patients. A subset of four species gave the strongest interaction. The presence of unclassified Enterococcus had the highest association with pressure ulcer occurrence. This study is the first to demonstrate that the cutaneous microbiome is altered in patients with pressure ulcers.
本研究旨在探究压疮患者与非压疮患者的无皮损皮肤微生物组组成是否存在差异。对 15 例骶尾部压疮患者和 15 例非压疮患者的无皮损皮肤微生物组进行了分析。结果表明，压疮患者皮肤微生物组的个体间变异性明显更高（P=0.01）。23 种细菌的丰度存在显著差异，金黄色葡萄球菌和未分类肠球菌是压疮患者中最丰富的两种细菌。随机森林模型显示，有 8 种细菌与 81%的压疮患者的发生有关。其中，有 4 种细菌的子集存在最强的相互作用。未分类肠球菌的存在与压疮的发生具有最高的关联性。本研究首次证明压疮患者的皮肤微生物组发生了改变。
