Pietrangelo Laura, Magnifico Irene, Guerrera Antonella, Cutuli Marco Alfio, Petronio Giulio Petronio, Venditti Noemi, Covelli Matteo, Buccieri Nicandro, Garofalo Silvio, Di Marco Roberto
Università degli Studi del Molise, Dipartimento di Medicina e Scienze della Salute "V. Tiberio", Campobasso, Italy.
Gea Medica srl, Istituto Europeo di Riabilitazione, Isernia, Italy.
Biomed Pharmacother. 2021 Dec;144:112327. doi: 10.1016/j.biopha.2021.112327. Epub 2021 Oct 13.
Pressure ulcers development is an undesirable event that often worsens the clinical condition of patients already affected by severe pathologies. Since the aetiology of this clinical complication is unclear yet, at current the primary approach to treat the problem is the adoption of suitable patients' assistance procedures. At the same time, the research focuses on finding medicaments or treatment strategies that could prevent the lesions and/or accelerate their healing. The international market's wide range of cosmetic/pharmaceuticals products is mainly topical preparations based on emollient agents to preserve or restore skin homeostasis. On the other hand, the skin microbiome's implication in the pressure ulcers occurrence is mainly unknown. Based on these assumptions, here we tested an innovative preparation, the LimpiAD foam, as a potential preventive strategy of pressure ulcers onset. The active component of this product is composed of hyaluronic acid conjugated with a bacterial cell wall fragment of C. acnes DSM 28251. For LimpiAD foam, we hypothesised a combined action of the two components on the skin tissue, an emollient effect due to the hyaluronic acid properties together with a modulatory effect on the skin microbiota carried out by the component of bacterial derivation. Our results supported the hypothesis and suggested a potential role of LimpiAD foam in pressure ulcers prevention.
压疮的发生是一种不良事件，常常会使已患有严重疾病的患者的临床状况恶化。由于这种临床并发症的病因尚不清楚，目前治疗该问题的主要方法是采用合适的患者护理程序。与此同时，研究集中在寻找能够预防损伤和/或加速其愈合的药物或治疗策略。国际市场上种类繁多的美容/药品产品主要是基于润肤剂的外用制剂，用于维持或恢复皮肤的稳态。另一方面，皮肤微生物群在压疮发生中的作用主要尚不清楚。基于这些假设，我们在此测试了一种创新制剂LimpiAD泡沫，作为预防压疮发生的潜在策略。该产品的活性成分由与痤疮丙酸杆菌DSM 28251的细菌细胞壁片段缀合的透明质酸组成。对于LimpiAD泡沫，我们假设两种成分对皮肤组织具有联合作用，即由于透明质酸的特性产生的润肤效果以及由细菌衍生成分对皮肤微生物群的调节作用。我们的结果支持了这一假设，并表明LimpiAD泡沫在预防压疮方面具有潜在作用。
