Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
Anesthesiology Service, Durham Veterans Affairs Health Care System, Durham, North Carolina, USA.
J Clin Invest. 2020 May 1;130(5):2164-2176. doi: 10.1172/JCI134439.
Regenerative pain medicine, which seeks to harness the body's own reparative capacity, is rapidly emerging as a field within pain medicine and orthopedics. It is increasingly appreciated that common analgesic mechanisms for these treatments depend on neuroimmune modulation. In this Review, we discuss recent progress in mechanistic understanding of nociceptive sensitization in chronic pain with a focus on neuroimmune modulation. We also examine the spectrum of regenerative outcomes, including preclinical and clinical outcomes. We further distinguish the analgesic mechanisms of regenerative therapies from those of cellular replacement, creating a conceptual and mechanistic framework to evaluate future research on regenerative medicine.
再生疼痛医学旨在利用人体自身的修复能力，正在迅速成为疼痛医学和骨科领域的一个分支。人们越来越认识到，这些治疗方法的常见镇痛机制依赖于神经免疫调节。在这篇综述中，我们讨论了慢性疼痛中伤害感受敏化的机制理解方面的最新进展，重点是神经免疫调节。我们还研究了再生治疗的再生结果谱，包括临床前和临床结果。我们进一步区分了再生疗法和细胞替代疗法的镇痛机制，为评估再生医学的未来研究创建了一个概念和机制框架。
