Durán M Teresa, Juget Frédéric, Nedjadi Youcef, Bochud François, Grundler Pascal V, Gracheva Nadezda, Müller Cristina, Talip Zeynep, van der Meulen Nicholas P, Bailat Claude
Institute of Radiation Physics, Lausanne, Switzerland.
Institute of Radiation Physics, Lausanne, Switzerland.
Appl Radiat Isot. 2020 May;159:109085. doi: 10.1016/j.apradiso.2020.109085. Epub 2020 Feb 19.
The radiolanthanide Tb is being studied as an alternative to Lu for targeted radionuclide tumor therapy. Both β-particle emitters show similar chemical behavior and decay characteristics, but Tb delivers additional conversion and Auger electron emissions that may enhance the therapeutic efficacy. In this study, the half-life of Tb was determined by a combination of three independent measurement systems: reference ionization chamber (CIR, chambre d'ionization de référence), portable ionization chamber (TCIR) and a CeBr γ-emission detector with digital electronics. The half-life determined for Tb is 6.953(2) days, showing a significant improvement in the uncertainty, which is one order of magnitude lower, with a deviation of 0.91% from the last nuclear data reference value. The previous large uncertainty of the half-life had a direct impact on activity measurements. Now it is no more an obstacle to a primary standardization.
放射性镧系元素铽（Tb）正在作为镥（Lu）的替代品进行靶向放射性核素肿瘤治疗研究。这两种β粒子发射体都表现出相似的化学行为和衰变特性，但铽会产生额外的转换电子发射和俄歇电子发射，这可能会增强治疗效果。在本研究中，铽的半衰期由三个独立测量系统组合确定：参考电离室（CIR，chambre d'ionization de référence）、便携式电离室（TCIR）和配备数字电子设备的溴化铈γ发射探测器。确定的铽半衰期为6.953(2)天，不确定性有显著改善，降低了一个数量级，与上次核数据参考值的偏差为0.91%。以前半衰期的不确定性较大，对活度测量有直接影响。现在它不再是初级标准化的障碍。
