Zeitlberger Anna Maria, Sosnova Marketa, Ziga Michal, Steinsiepe Valentin, Gautschi Oliver P, Stienen Martin N, Maldaner Nicolai
Department of Neurosurgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Neuro- and Spine Center, Hirslanden Clinic St. Anna, Lucerne, Switzerland.
Neurospine. 2020 Mar;17(1):136-142. doi: 10.14245/ns.2040022.011. Epub 2020 Mar 31.
Epidural steroid injection (ESI) represents a popular treatment option in patients with lumbar degenerative disc disease (DDD). The main objective of the article was to determine whether the 6-minute walking test (6WT) could assist in the discrimination between ESI responders and nonresponders. We used a validated 6WT smartphone application to assess self-measured objective functional impairment (OFI) in 3 patients with DDD undergoing ESI. Patient-reported outcome measures (PROMs), including the Core Outcome Measures Index and the Oswestry Disability Index, were obtained at baseline and at the 3-, 7-, and 28-day follow-up. Descriptive analyses were used to compare PROMs with OFI over time. Two patients responded well to the ESI, illustrated by clinically meaningful improvements in PROMs. This improvement was accompanied by a substantial increase in the 6WT distance (case I: 358 m vs. 517 m and case II: 296 m vs. 625 m). One patient reported only moderate improvement in leg pain and conflicting results in the other PROMs. The 6WT demonstrated a persistent OFI (487 m vs. 488 m). This patient was considered a nonresponder and underwent surgical treatment. This case series illustrates the feasibility of the smartphone-based 6WT as a tool to assess OFI in patients undergoing ESI for lumbar DDD.
硬膜外类固醇注射(ESI)是腰椎退行性椎间盘疾病(DDD)患者常用的治疗选择。本文的主要目的是确定6分钟步行试验(6WT)是否有助于区分ESI治疗的反应者和无反应者。我们使用一款经过验证的6WT智能手机应用程序,对3例接受ESI治疗的DDD患者的自我测量客观功能障碍(OFI)进行评估。在基线以及随访的第3天、第7天和第28天,获取患者报告的结局指标(PROMs),包括核心结局指标指数和Oswestry功能障碍指数。采用描述性分析比较不同时间点的PROMs和OFI。2例患者对ESI反应良好,PROMs有临床意义的改善。这种改善伴随着6WT步行距离的大幅增加(病例I:358米对517米,病例II:296米对625米)。1例患者仅报告腿痛有中度改善,其他PROMs结果相互矛盾。6WT显示OFI持续存在(487米对488米)。该患者被视为无反应者并接受了手术治疗。这个病例系列说明了基于智能手机的6WT作为评估接受ESI治疗腰椎DDD患者OFI工具的可行性。