The Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
University of Chinese Academy of Sciences, Beijing, China.
Nat Prod Res. 2021 Nov;35(21):3918-3924. doi: 10.1080/14786419.2020.1749612. Epub 2020 Apr 6.
Three new highly oxygenated lanostane triterpenoids, applanaic acids A-C (-), were isolated from the fruiting bodies of the basidiomycete Among them, applanaic acid B () possessed the Δ-double bond connection between the side chain and the tetracyclic skeleton, which was not common in the natural lanostane triterpenoids. Their structures were determined by 1D, 2D NMR and HRESIMS spectroscopic analysis. Compound showed a weak acetylcholinesterase (AchE) inhibitory activity with 33.5% inhibition rate at 50 μM.[Figure: see text].
从担子菌的子实体中分离得到三种新的高度氧化的羊毛甾烷三萜酸，即 applanaic 酸 A-C（-）。其中，applanaic 酸 B（）具有侧链和四环骨架之间的Δ-双键连接，这在天然羊毛甾烷三萜中并不常见。它们的结构通过 1D、2D NMR 和 HRESIMS 光谱分析确定。化合物 显示出较弱的乙酰胆碱酯酶（AchE）抑制活性，在 50μM 时抑制率为 33.5%。[图：见正文]。
