School of Pharmaceutical Science, Guangxi Medical University, 22 Shuangyong Road, Nanning, 530021, China.
School of Pharmaceutical Science, Guangxi Medical University, 22 Shuangyong Road, Nanning, 530021, China.
Phytochemistry. 2020 Sep;177:112453. doi: 10.1016/j.phytochem.2020.112453. Epub 2020 Jul 9.
Five previously undescribed lanostane-type triterpenoids, including two triterpenoids with a rearranged side chain (applanoic acids E and F), one C21 nortriterpenoid (16,17-dehydroapplanone E), as well as two highly oxygenated lanostane triterpenoids (methyl applaniate B and applanoic acid G), were isolated from the fruiting bodies of Ganoderma applanatum (Pers.) Pat. Their structures were elucidated on the basis of spectroscopic analysis, X-ray crystallography and ECD data. Applanoic acid E, 16,17-dehydroapplanone E, and methyl applaniate B showed inhibitory effects on the release of NO by LPS-induced BV-2 cells.
从平盖灵芝（Ganoderma applanatum（Pers.）Pat.）的子实体中分离得到五个以前未描述过的羊毛甾烷型三萜类化合物，包括两个具有重排侧链的三萜类化合物（阿朴兰酸 E 和 F）、一个 C21 降三萜（16,17-去氢阿朴兰酮 E），以及两个高度氧化的羊毛甾烷三萜（甲基阿朴兰酸 B 和阿朴兰酸 G）。基于光谱分析、X 射线晶体学和 ECD 数据阐明了它们的结构。阿朴兰酸 E、16,17-去氢阿朴兰酮 E 和甲基阿朴兰酸 B 对 LPS 诱导的 BV-2 细胞中 NO 的释放具有抑制作用。
