薄树芝中羊毛甾烷型三萜及其对 LPS 诱导的 BV-2 细胞中 NO 生成的抑制活性。
Lanostane-type triterpenoids from Ganoderma applanatum and their inhibitory activities on NO production in LPS-induced BV-2 cells.
机构信息
School of Pharmaceutical Science, Guangxi Medical University, 22 Shuangyong Road, Nanning, 530021, China.
School of Pharmaceutical Science, Guangxi Medical University, 22 Shuangyong Road, Nanning, 530021, China.
出版信息
Phytochemistry. 2020 Sep;177:112453. doi: 10.1016/j.phytochem.2020.112453. Epub 2020 Jul 9.
Five previously undescribed lanostane-type triterpenoids, including two triterpenoids with a rearranged side chain (applanoic acids E and F), one C21 nortriterpenoid (16,17-dehydroapplanone E), as well as two highly oxygenated lanostane triterpenoids (methyl applaniate B and applanoic acid G), were isolated from the fruiting bodies of Ganoderma applanatum (Pers.) Pat. Their structures were elucidated on the basis of spectroscopic analysis, X-ray crystallography and ECD data. Applanoic acid E, 16,17-dehydroapplanone E, and methyl applaniate B showed inhibitory effects on the release of NO by LPS-induced BV-2 cells.
从平盖灵芝（Ganoderma applanatum（Pers.）Pat.）的子实体中分离得到五个以前未描述过的羊毛甾烷型三萜类化合物，包括两个具有重排侧链的三萜类化合物（阿朴兰酸 E 和 F）、一个 C21 降三萜（16,17-去氢阿朴兰酮 E），以及两个高度氧化的羊毛甾烷三萜（甲基阿朴兰酸 B 和阿朴兰酸 G）。基于光谱分析、X 射线晶体学和 ECD 数据阐明了它们的结构。阿朴兰酸 E、16,17-去氢阿朴兰酮 E 和甲基阿朴兰酸 B 对 LPS 诱导的 BV-2 细胞中 NO 的释放具有抑制作用。
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