Shandong Provincial Key Laboratory of Applied Mycology, College of Life Sciences, Qingdao Agricultural University, Qingdao, China.
Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
Nat Prod Res. 2022 Mar;36(6):1529-1535. doi: 10.1080/14786419.2021.1898388. Epub 2021 Mar 26.
Two new lanostane-type triterpenoids, ganoderenicfys A () and B (), together with six related known terpenoids (-), were isolated and identified from the fruiting body of . The structures of these compounds were established on the basis of detailed interpretation of their NMR and HRESIMS data. The absolute configurations of and were determined by quantum chemical electronic circular dichroism (ECD) calculations. All of the isolated compounds were evaluated for their proangiogenic activities in a transgenic fluorescent zebrafish model. Compounds - displayed dose-dependently proangiogenic activity in a PTK787-induced vascular injury zebrafish model, while compounds , and significantly promoted the angiogenesis. This is the first report for proangiogenic activities of lanostane-type triterpenoids.
两种新的羊毛甾烷型三萜类化合物， ganoderenicfys A()和 B()，以及六种相关的已知萜类化合物 (-)，从灵芝的子实体中分离和鉴定出来。这些化合物的结构是根据它们的 NMR 和 HRESIMS 数据的详细解释确定的。和的绝对构型是通过量子化学电子圆二色性 (ECD) 计算确定的。所有分离得到的化合物均在转基因荧光斑马鱼模型中进行了促血管生成活性评价。化合物-在 PTK787 诱导的血管损伤斑马鱼模型中表现出剂量依赖性的促血管生成活性，而化合物、和则显著促进了血管生成。这是羊毛甾烷型三萜类化合物促血管生成活性的首次报道。
