Musa Sherief
Endemic Hepatogastroenterology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Arab J Gastroenterol. 2020 Mar;21(1):3-8. doi: 10.1016/j.ajg.2020.03.002. Epub 2020 Apr 3.
Since December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19), has posed a serious threat to global health and is currently causing a major pandemic. While patients typically present with fever and a respiratory illness, mounting evidence indicates that patients might also report extra-pulmonary manifestations, including those affecting the liver and gastrointestinal tract. This involvement may have important implications to the disease management, transmission, and prognosis, especially in patients with pre-existing hepatic or digestive co-morbidities. In this review, the characteristics and possible explanations of hepatic and gastrointestinal involvement caused by SARS-CoV-2 infection are summarized, adding to our knowledge of the spectrum of COVID-19. In addition, preventive measures implemented in endoscopy departments to prevent further dissemination of SARS-CoV-2 infection are proposed.
自2019年12月以来，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）作为2019冠状病毒病（COVID-19）的病原体，对全球健康构成了严重威胁，目前正在引发一场大流行。虽然患者通常表现为发热和呼吸道疾病，但越来越多的证据表明，患者也可能出现肺外表现，包括影响肝脏和胃肠道的表现。这种累及可能对疾病的管理、传播和预后具有重要意义，尤其是在患有肝脏或消化系统合并症的患者中。在这篇综述中，总结了SARS-CoV-2感染引起的肝脏和胃肠道累及的特征及可能的解释，增进了我们对COVID-19谱系的认识。此外，还提出了在内镜科室实施的预防SARS-CoV-2感染进一步传播的措施。
