Gjessing J, Tomlin P J
Anaesthesia. 1977 Jan;32(1):63-9. doi: 10.1111/j.1365-2044.1977.tb11561.x.
A double-blind study of 229 patients with the use of intravenous diazepam as compared with a placebo to produce sedation during local analgesia showed that significantly improved sedation occurred when diazepam was used. The diazepam was dissolved in cremophor and this reduced the pain of intravenous injection of the diazepam. One patient who received Cremophor only, showed a moderately severe allergic reaction. It is suggested that a small test dose should always be given before giving any drug which is dissolved in Cremophor.
一项针对229例患者的双盲研究，比较了静脉注射地西泮与安慰剂在局部镇痛期间产生镇静作用的效果，结果显示使用地西泮时镇静效果显著改善。地西泮溶解于聚氧乙烯蓖麻油中，这减轻了静脉注射地西泮时的疼痛。仅接受聚氧乙烯蓖麻油的一名患者出现了中度严重的过敏反应。建议在给予任何溶解于聚氧乙烯蓖麻油的药物之前，都应始终先给予小剂量试验。
