The State Key Laboratory for Refractories and Metallurgy, Institute of Advanced Materials and Nanotechnology, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China.
Nanoscale. 2020 Apr 30;12(16):8679-8686. doi: 10.1039/d0nr01736a.
Stimuli-responsive hydrogels with adaptable physical properties show great potential in the biomedical field. In particular, the collection of electrical signals is essential for precision medicine. Here, a simple strategy is demonstrated for achieving controlled drug release and real-time monitoring using an interpenetrating binary network consisting of a graphene aerogel and a poly(N-isopropylacrylamide) hydrogel with incorporated polydopamine nanoparticles (PDA-NPs). Owing to the good physical properties of graphene and the embedded PDA-NPs, the hybrid hydrogel shows enhanced mechanical properties and good electrical conductivity. In addition, the hybrid hydrogel also shows dual thermo- and near-infrared light responsiveness, as revealed by the controlled release of a model drug. In addition, as the hydrogel exhibits detectable changes in resistance during drug release, the drug-release behavior of the hydrogel can be monitored in real time using electrical signals. Moreover, owing to the abundance of catechol groups on the PDA-NPs, the hybrid hydrogel shows good tissue adhesiveness, as demonstrated using in vivo experiments. Thus, the developed hybrid hydrogel exhibits considerable practical applicability for drug delivery and precision medicine.
具有自适应物理性能的刺激响应水凝胶在生物医学领域具有巨大的应用潜力。特别是，电信号的采集对于精准医疗至关重要。在这里，展示了一种简单的策略，通过使用由石墨烯气凝胶和掺入聚（N-异丙基丙烯酰胺）水凝胶的聚多巴胺纳米颗粒（PDA-NPs）组成的互穿二元网络来实现控制药物释放和实时监测。由于石墨烯和嵌入的 PDA-NPs 的良好物理性能，混合水凝胶表现出增强的机械性能和良好的导电性。此外，混合水凝胶还表现出双重热和近红外光响应性，这可以通过模型药物的控制释放来揭示。此外，由于水凝胶在药物释放过程中表现出可检测的电阻变化，因此可以使用电信号实时监测水凝胶的药物释放行为。此外，由于 PDA-NPs 上丰富的儿茶酚基团，混合水凝胶表现出良好的组织粘附性，这可以通过体内实验证明。因此，开发的混合水凝胶在药物输送和精准医疗方面具有相当大的实际应用价值。
