Lian Yanbang, Wang Congcong, Meng Yu, Dong Junqiang, Zhang Jianbin, Xu Shiqing, Bai Gongxun, Gao Jianbo
Radiology Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province, College of Optical and Electronic Technology, China Jiliang University, Hangzhou, Zhejiang 310018, China.
ACS Omega. 2023 Mar 3;8(10):9371-9378. doi: 10.1021/acsomega.2c07964. eCollection 2023 Mar 14.
Photothermal therapy has been regarded as one of promising ways for tumor treatment. However, nanoagents with highly efficient thermal conversion and good bio-compatibility are still needed to be developed in biomedicine. In this work, we prepared two-dimensional heterostructures with bismuth selenide and tungsten selenide nanosheets as photothermal nanoagents. Near-infrared photothermal conversion of selenide heterostructure nanosheets can reach up to 40.75% under 808 nm excitation. It is known that selenium is a critical element to human health. More importantly, our experiments with mice show that the heterostructure nanosheets have low toxicity and high biocompatibility both in vitro and in vivo. The nanoagents based on heterostructures can effectively realize photothermal tumor ablation. It is suggested that the developed selenide nanosheets have great potential application in cancer therapy.
光热疗法被认为是肿瘤治疗的一种有前景的方法。然而，在生物医学领域仍需要开发具有高效热转换和良好生物相容性的纳米剂。在这项工作中，我们制备了以硒化铋和硒化钨纳米片作为光热纳米剂的二维异质结构。在808 nm激发下，硒化物异质结构纳米片的近红外光热转换效率可达40.75%。众所周知，硒是对人体健康至关重要的元素。更重要的是，我们对小鼠的实验表明，这种异质结构纳米片在体外和体内均具有低毒性和高生物相容性。基于异质结构的纳米剂能够有效地实现光热肿瘤消融。这表明所开发的硒化物纳米片在癌症治疗中具有巨大的潜在应用价值。
