Xiao Yunchao, Shen Mingwu, Shi Xiangyang
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P. R. China.
J Mater Chem B. 2018 Mar 14;6(10):1420-1432. doi: 10.1039/c7tb03347h. Epub 2018 Feb 15.
Electrospun nanofibers possess an extremely large surface area to volume ratio, good biocompatibility, ability to mimic native extracellular matrix, and the advantages of easy preparation and surface functionalization. These properties enable them to be used as an ideal platform for cancer cell capture applications. This review reports some recent advances in the use of nanofibers for cancer cell capture applications, in particular, preparation and surface functionalization of nanofibers with targeting molecules, static capture of cancer cells using nanofibrous substrates, dynamic capture of cancer cells and circulating tumor cells using fiber-integrated microfluidic platforms, and strategies used to release the captured cancer cells. Some of the key developments are introduced and summarized in detail; future perspectives are also briefly discussed.
电纺纳米纤维具有极大的表面积与体积比、良好的生物相容性、模拟天然细胞外基质的能力以及易于制备和表面功能化的优点。这些特性使其能够用作癌细胞捕获应用的理想平台。本综述报道了纳米纤维在癌细胞捕获应用方面的一些最新进展，特别是纳米纤维与靶向分子的制备及表面功能化、使用纳米纤维基质静态捕获癌细胞、使用纤维集成微流控平台动态捕获癌细胞和循环肿瘤细胞，以及用于释放捕获的癌细胞的策略。详细介绍并总结了一些关键进展；还简要讨论了未来展望。
