Marques L M, Alves M M, Eugénio S, Salazar S B, Pedro N, Grenho L, Mira N P, Fernandes M H, Montemor M F
CQE, Instituto Superior Técnico, Departamento de Engenharia Química, Universidade de Lisboa, Avenida Rovisco Pais, 1049-001, Lisboa, Portugal.
J Mater Chem B. 2018 May 14;6(18):2821-2830. doi: 10.1039/c7tb02726e. Epub 2018 Apr 20.
Zinc (Zn)-derived foams have been prepared from an alkaline electrolyte solution by galvanostatic electrodeposition under different conditions. A detailed physico-chemical characterization was performed by Raman spectroscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM). A pioneer application of these foams in medical implant-related applications was investigated. The in vitro behaviour of these Zn-derived foams in simulated physiological conditions was studied. The results revealed that the presence of zinc oxide was important enough to change the in vitro behaviour of these materials. The potential of these Zn-derived foams in inhibiting bone cancer cell proliferation - osteoscarcoma cells - and important pathogenic fungi responsible for implant-related infections -Candida albicans- was examined. Furthermore, the foams were evaluated for cytocompatibility with normal human osteoblasts. The results obtained allowed us to conclude that Zn-derived foams have an interesting potential for anti-cancer and anti-Candida activity, targeted for bone-related implant applications, suggesting that this novel material may have potential for further clinical studies.
通过在不同条件下进行恒电流电沉积，从碱性电解质溶液中制备了锌（Zn）基泡沫材料。利用拉曼光谱、X射线衍射（XRD）和扫描电子显微镜（SEM）对其进行了详细的物理化学表征。研究了这些泡沫材料在与医疗植入物相关应用中的开创性应用。研究了这些锌基泡沫材料在模拟生理条件下的体外行为。结果表明，氧化锌的存在对改变这些材料的体外行为具有足够重要的影响。研究了这些锌基泡沫材料抑制骨肉瘤细胞（骨癌细胞）增殖以及引起植入物相关感染的重要致病真菌——白色念珠菌的潜力。此外，还评估了这些泡沫材料与正常人成骨细胞的细胞相容性。所获得的结果使我们能够得出结论，锌基泡沫材料在针对骨相关植入物应用的抗癌和抗念珠菌活性方面具有有趣的潜力，这表明这种新型材料可能具有进一步进行临床研究的潜力。
