Vinogradov Vladimir V, Drozdov Andrey S, Mingabudinova Leila R, Shabanova Emiliya M, Kolchina Nina O, Anastasova Elizaveta I, Markova Alina A, Shtil Alexander A, Milichko Valentin A, Starova Galina L, Precker Rafaella L M, Vinogradov Alexandr V, Hey-Hawkins Evamarie, Pidko Evgeny A
Laboratory of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova st. 9, Saint-Petersburg, 197101, Russian Federation.
J Mater Chem B. 2018 Apr 28;6(16):2450-2459. doi: 10.1039/c8tb00072g. Epub 2018 Apr 12.
We describe the synthesis and properties of a new composite material based on heparin and MIL-101(Fe) metal-organic framework. The intrinsic instability of MIL-101(Fe) towards hydrolysis enables binding of heparin molecules to the framework structure as is evidenced by DFT calculations and adsorption experiments. The de novo formed heparin-MOF composites showed good biocompatibility in in vitro and demonstrated pronounced anticoagulant activity. The specific interaction between the bioactive molecule and the carrier is critical for the selective degradation of the complex in the body fluids and for the enhanced activity. Hep_MIL-101(Fe) composite could serve as a drug-releasing depot for nanofabrication and to introduce anticoagulant activity to medical devices and biocoatings. Addition of Hep_MIL-101(Fe) to a sol-gel derived thrombolytic matrix allowed the combination of anticoagulant and thrombolytic activities in a single hybrid nanomaterial that could be applied as a bioactive nanocoating for PTFE vein implants.
我们描述了一种基于肝素和MIL-101(Fe)金属有机框架的新型复合材料的合成及性能。MIL-101(Fe)对水解的固有不稳定性使得肝素分子能够与框架结构结合，这一点已通过密度泛函理论计算和吸附实验得到证实。新形成的肝素-金属有机框架复合材料在体外显示出良好的生物相容性，并表现出显著的抗凝活性。生物活性分子与载体之间的特异性相互作用对于复合物在体液中的选择性降解以及增强活性至关重要。Hep_MIL-101(Fe)复合材料可作为纳米制造的药物释放库，并为医疗设备和生物涂层引入抗凝活性。将Hep_MIL-101(Fe)添加到溶胶-凝胶衍生的溶栓基质中，可在单一杂化纳米材料中实现抗凝和溶栓活性的结合，该材料可作为聚四氟乙烯静脉植入物的生物活性纳米涂层。
