Conner J T, Bellville J W, Wender R H, Wapner S, Katz R L
Anesth Analg. 1977 Mar-Apr;56(2):211-5. doi: 10.1213/00000539-197703000-00009.
Intravenous diazepam was administered to 4 groups of 35 patients as a surgical premedicant, double blind and according to a randomized sequence. Four dosages were used: 2.5, 5, 10, and 20 mg. Amnesia, relief of anxiety, sedation, and patient acceptance were primarily evaluated. While a significant linear dose effect was found for sedation, anxiety releief, and patient acceptance, this was not true for anmesia, which was clinically present only with doses of 10 and 20 mg. No significant adverse effects were noted at any dosage, and vital signs remained stable in all patients studied.
将静脉注射地西泮作为手术前用药，以双盲方式并按照随机顺序给予4组患者，每组35例。使用了4种剂量：2.5毫克、5毫克、10毫克和20毫克。主要评估失忆、焦虑缓解、镇静和患者接受度。虽然在镇静、焦虑缓解和患者接受度方面发现了显著的线性剂量效应，但失忆并非如此，临床上仅在10毫克和20毫克剂量时出现失忆。任何剂量均未观察到显著不良反应，且所有研究患者的生命体征均保持稳定。
