Gao Wenbin, Li Qin, Dou Meiling, Zhang Zhengping, Wang Feng
State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Electrochemical Process and Technology for Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China.
J Mater Chem B. 2018 Nov 14;6(42):6781-6787. doi: 10.1039/c8tb02058b. Epub 2018 Oct 11.
High-precision, non-enzymatic electrochemical detection of glucose is of vital importance for the diagnosis and treatment of diabetes mellitus. To meet this requirement, a facile and effective strategy for creating glucose-sensitive detective materials with high sensitivity and selectivity is demonstrated via the synthesis of Ni nanoparticles self-supported on N-doped carbon (Ni/NC) by direct pyrolysis of cross-linked nickel polyphthalocyanine (NiPPc) for non-enzymatic glucose detection. Owing to the extended electronic structure of the N-doped carbon supports and the considerable improvement in charge/mass transport, the resultant Ni/NC sample exhibits excellent activity and long-term reusability in non-enzymatic glucose detection, with a sensitivity of 660.3 μA mM cm and a rather low detection limit of 0.12 μM, along with a wide linear range of 2 μM to 4.658 mM. The facile and promising synthetic strategy of Ni-based sensors for non-enzymatic glucose detection may offer an advanced alternative to noble metal and enzymatic sensors for the diagnosis of diabetes mellitus, and may promote the development of such materials in medical technology.
高精度、非酶电化学检测葡萄糖对于糖尿病的诊断和治疗至关重要。为满足这一需求，通过直接热解交联镍酞菁（NiPPc）合成自支撑于氮掺杂碳（Ni/NC）上的镍纳米颗粒，展示了一种简便有效的策略来制备具有高灵敏度和选择性的葡萄糖敏感检测材料用于非酶葡萄糖检测。由于氮掺杂碳载体的扩展电子结构以及电荷/质量传输的显著改善，所得的Ni/NC样品在非酶葡萄糖检测中表现出优异的活性和长期可重复使用性，灵敏度为660.3 μA mM cm，检测限相当低，为0.12 μM，线性范围宽达2 μM至4.658 mM。这种用于非酶葡萄糖检测的镍基传感器简便且有前景的合成策略可能为糖尿病诊断中的贵金属和酶传感器提供一种先进的替代方案，并可能推动此类材料在医疗技术中的发展。
